نبذة مختصرة : Introduction: Psychosomatic diseases disrupt patients’ mental order, leading to chronic psychological injuries. Consequently, this study aimed to investigate the mediating role of health-promoting behaviors in the relationship between perceived stress and sense of coherence with psychosocial adaptation to the disease in patients with irritable bowel syndrome (IBS).Methods: The research method was descriptive-correlational and utilized Structural Equation Modeling. The study’s statistical population included patients with IBS referred to therapy centers and gastroenterologists in Isfahan in the autumn and winter of 2020-21. The statistical population comprised 340 patients with IBS, selected using a convenient sampling method. The applied instruments included the Psycho-Social Adaptation to Disease Scale (PSADS), Perceived Stress Scale (PSS) Sense of Coherence Questionnaire (SCQ) and Health Promoting Behaviors Questionnaire (HPBQ). Data analysis was conducted via Structural Equation Modeling and Bootstrap test using SPSS23 and AMOS23 statistical software.Results: The results showed that perceived stress, sense of coherence, and health-promoting behaviors directly affect psychosocial adaptation to disease. Furthermore, the results of the Bootstrap test showed that health-promoting behaviors have a significant mediation role in the relationship of perceived stress and sense of coherence with psychosocial adaptation to disease (P
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