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Donor-Specific Anti-Human Leukocyte Antigen Antibodies Predict Prolonged Isolated Thrombocytopenia and Inferior Outcomes of Haploidentical Hematopoietic Stem Cell Transplantation

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  • معلومة اضافية
    • بيانات النشر:
      Hindawi Limited, 2017.
    • الموضوع:
      2017
    • Collection:
      LCC:Immunologic diseases. Allergy
    • نبذة مختصرة :
      Prolonged isolated thrombocytopenia (PT) after allogeneic stem cell transplantation (allo-SCT) has a great impact on transplant outcome. In this study, we performed a retrospective analysis to investigate the association of donor-specific anti-human leukocyte antigen (HLA) antibodies (DSAs) with PT in 394 patients who underwent unmanipulated haploidentical blood and marrow transplantation (HBMT). For HLA antibody positive samples with a median fluorescent intensity (MFI) > 500, DSAs were further examined. A total of 390 patients (99.0%) achieved sustained myeloid engraftment. Of the 394 cases tested, 45 (11.4%) were DSA positive. The cumulative incidence of PT in this cohort of patients was 9.9 ± 1.5%. The incidence of PT was higher in patients with a MFI ≥ 1000 compared with those with a MFI
    • File Description:
      electronic resource
    • ISSN:
      2314-8861
      2314-7156
    • Relation:
      https://doaj.org/toc/2314-8861; https://doaj.org/toc/2314-7156
    • الرقم المعرف:
      10.1155/2017/1043836
    • الرقم المعرف:
      edsdoj.972139ff30d14d1fa3de254fea1504dc