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Ibrutinib reverses IL-6-induced osimertinib resistance through inhibition of Laminin α5/FAK signaling

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  • معلومة اضافية
    • بيانات النشر:
      Nature Portfolio, 2022.
    • الموضوع:
      2022
    • Collection:
      LCC:Biology (General)
    • نبذة مختصرة :
      The resistance mechanism of osimertinib, a third-generation EGFR-TKI, is mediated by IL-6 and Laminin α5/FAK signaling. Ibrutinib combined with osimertinib is presented as a strategy for overcoming osimertinib acquired resistance in EGFR mutant NSCLC.
    • File Description:
      electronic resource
    • ISSN:
      2399-3642
    • Relation:
      https://doaj.org/toc/2399-3642
    • الرقم المعرف:
      10.1038/s42003-022-03111-7
    • الرقم المعرف:
      edsdoj.92d470bd40864ffaab02b316aff97dc9