Differential Impact of Subcutaneous Neurokinin B Administration on Epididymal Proliferation in Adult New Zealand White Rabbits: A Dose-Dependent Study

Objective: To investigate the potential of variable doses of Neurokinin B on histomorphology of epididymis in adult rabbits. Study Design: Laboratory-based experimental study. Place and Duration of Study: Gomal Centre of Biochemistry and Biotechnology, Gomal University, Dera Ismail Khan, Pakistan, from Jun 2019 to Jun 2020. Methodology: Adult male New Zealand White rabbits with an average weight of 1.5–2 Kg were randomly assigned to three groups. Study animals were administered subcutaneously with Neurokinin B in two variable doses: 1 µg and one ηg. Control rabbits were injected with distilled water in parallel. After 12 days of continuous peptide treatment, animals (n=06) in each group were sacrificed. Epididymis were dissected and processed for light microscopy and sperm count. Results: Mean epididymis weight (mg) increased significantly (p