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Association of carotid atherosclerosis and peripheral artery disease in patients with type 2 diabetes: risk factors and biomarkers

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اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • بيانات النشر:
      Endocrinology Research Centre, 2023.
    • الموضوع:
      2023
    • Collection:
      LCC:Nutritional diseases. Deficiency diseases
    • نبذة مختصرة :
      BACKGROUND: Carotid atherosclerosis (CA) and lower extremity peripheral artery disease (PAD) is a common and potentially life-threatening comorbidity in diabetes.AIM: to determine risk factors and biomarkers of the association of CA and PAD in patients with type 2 diabetes.MATERIALS AND METHODS: A single-center cross-sectional comparative study was carried out. Three hundred ninety one patients with type 2 diabetes were included. Duplex ultrasound of carotid and low limb arteries, screening/monitoring of diabetic complications and associated diseases, and assessment of glycemic control, biochemical and coagulation parameters were performed. Factors involved in vascular wall remodeling, including calponin-1, relaxin, L-citrulline, matrix metalloproteinase-2 and -3, were measured in blood serum by ELISA.RESULTS: The signs of CA and PAD were observed in 330 and 187 patients respectively. In 178 patients, both CA and PAD were revealed. The risk of combined involvement of carotid and lower extremity arteries was higher in patients with diabetic retinopathy (OR=2.57, p
    • File Description:
      electronic resource
    • ISSN:
      2072-0351
      2072-0378
    • Relation:
      https://www.dia-endojournals.ru/jour/article/view/12915; https://doaj.org/toc/2072-0351; https://doaj.org/toc/2072-0378
    • الرقم المعرف:
      10.14341/DM12915
    • الرقم المعرف:
      edsdoj.845c5561c4c342a3bda937dc01c8ef47