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Mitochondrial targeted meganuclease as a platform to eliminate mutant mtDNA in vivo

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اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • بيانات النشر:
      Nature Portfolio, 2021.
    • الموضوع:
      2021
    • Collection:
      LCC:Science
    • نبذة مختصرة :
      Heteroplasmic mitochondrial DNA mutations lack effective treatments. Here the authors adapt I-CreI meganuclease to target the mitochondria and specifically-eliminate mtDNA with a m.5024C>T mutation in the mttRNA Ala gene.
    • File Description:
      electronic resource
    • ISSN:
      2041-1723
    • Relation:
      https://doaj.org/toc/2041-1723
    • الرقم المعرف:
      10.1038/s41467-021-23561-7
    • الرقم المعرف:
      edsdoj.7f6099041724090957f81336f63c028