نبذة مختصرة : Introduction Oxidative stress and antibiotic resistance are currently a major public health problem; hence, the search for new sources of anti-infective agents is essential. Purpose The aim of the present study was to determine the micrographic profile of Solanum lycopersicum leaves and Curcuma longa rhizomes; and to evaluate the bio-optimisation of the antioxidant and antibacterial activity of Solanum lycopersicum by association with Curcuma longa extract. Methods The powder was observed using the Steimetz reagent, while antibacterial activity was assessed using the microdilution method in a liquid medium, and antioxidant activity was assessed using the free radical scavenging test with DPPHº and ABTS. Results The study showed that the powders of these two species have characteristic elements such as starch grains, fragments of spiral vessels, etc. The antioxidant power of the combination of extracts was greater than that recorded with Solanum lycopersicum alone, at the same concentrations, by the two tests used. The antibacterial activity revealed that the synergy of extracts from these two plants was effective against most of the strains tested, even at very low doses in some cases. Conclusion These results provide a basis for validating combinations of different plant extracts in the pharmacopoeia of the Democratic Republic of the Congo.
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