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Safety of interferon β-1a for treatment of COVID-19: a real-world study based on FAERS database
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- معلومة اضافية
- بيانات النشر:
Shanghai Preventive Medicine Association, 2023.
- الموضوع:
2023
- Collection:
LCC:Medicine
- نبذة مختصرة :
ObjectiveTo systematically evaluate the safety of interferon β-1a for treatment of corona virus disease 2019 (COVID-19), and to provide references for interferon β-1a's clinical application.MethodsThis study was conducted with the database from US Food and Drug Administration adverse event reporting system (FAERS) from January 1, 2015 to March 31, 2021. Information component (IC) and reporting odds ratio (ROR) methods were applied for signal mining.ResultsA total of 463 700 records of COVID-19 were selected for analysis, and 45 positive drug adverse event signals were detected. Headache (IC025=1.09, ROR025=2.28), pyrexia (IC025=0.51, ROR025=1.51) and multiple sclerosis relapse (IC025=3.67, ROR025=14.71) were positive adverse events with higher frequency. Autoimmune disorder (IC025=4.42, ROR025=24.03), streptococcal infection (IC025=4.12, ROR025=19.82), and multiple sclerosis relapse (IC025=3.67, ROR025=14.71) were positive adverse events. Acute lung injury, cardio-respiratory arrest and metabolic acidosis were associated with a higher proportion and frequency of death.ConclusionThere are certain safety issues with interferon β-1a in the treatment of COVID-19, and some adverse events with high frequency and high death rate deserve further attention by medical staffs.
- File Description:
electronic resource
- ISSN:
1004-9231
- Relation:
https://doaj.org/toc/1004-9231
- الرقم المعرف:
10.19428/j.cnki.sjpm.2023.22768
- الرقم المعرف:
edsdoj.4d99a84451204546a924f084ab7027c9
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