نبذة مختصرة : Background: Type 2 diabetes mellitus (T2DM) has primarily been managed with modern medicine, which is often target-based and nonholistic, leading to long-term adverse effects. Whereas, integrated-pathy is based on the principles of appropriate application of complementary treatments to support the body’s natural healing abilities. It incorporates a range of treatments, including ancient healing practices such as Yoga, Yagya, Ayurveda, Diet, Naturopathy, Pancha-Karma, and diverse Relaxation Techniques along with comprehensive strategies for the management of T2DM. Objective: To assess the effectiveness of integrated-pathy on physiological, biochemical, psychological, and anthropometric parameters in T2DM patients. Materials and Methods: Based on statistical calculations using G*Power 3.1.9.7, 53 T2DM patients aged (50.26 ± 9.13) years were selected using the convenient sampling. The normality of data (p > 0.05) was checked using the Shapiro–Wilk test in SPSS version 24.0. Psychological variables (quality of life, Depression Anxiety and Stress Scale, and Quality of Diabetes Self-Care) measured at three-time points (day 0, day 7, and day 45), were analyzed with the analysis of variance followed by Bonferroni-adjusted post hoc tests to control type 1 error. Glucose and cholesterol levels were assessed on day 0 and day 45, while treatment satisfaction was assessed on day 0 and day 7 and analyzed using paired t-tests. Results: The inclusion rate of participants was 48.18% with 36 female and 17 male participants. 66.03% of the participants were physically active or moderately active, rest 33.97% were least active or had a sedentary lifestyle. A decrease in weight (1.55%), BMI (1.59%), respiratory rate (6.85%), and systolic blood pressure (4.57%) was observed at the end of 7 day. By the end of 45th day a 4.7% reduction in HbA1c levels (p = 0.003), a 9.44% reduction in postprandial glucose (p = 0.46), and a 10.9% reduction in fasting glucose were noted. Regarding lipid profile markers, there was a slight increase in LDL cholesterol (0.5%) and a significant increase in HDL cholesterol (10.65%, p
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