Advances in the study of tumor markers for intracranial germ cell tumors

Intracranial germ cell tumors (ICGCTs) are highly heterogeneous tumors that tend to occur in children and adolescents, and their diagnosis and treatment strategies are closely related to their pathological components. However, due to their low surgical treatment rate, limited access to pathological specimens of tumors, and difficult or incomplete pathological biopsy, it is difficult to make clinical diagnosis and treatment. Specific tumor markers play an important role in the auxiliary diagnosis, treatment and prognosis prediction of ICGCTs. This paper intends to review the studies on classical histological markers, serology and/or cerebrospinal fluid tumor markers of ICGCTs, so as to provide references for clinical application and research. DOI：10.3969/j.issn.1672⁃6731.2020.04.004