Multimodal Framework in Lung Cancer Management: Integrating Liquid Biopsy with Traditional Diagnostic Techniques

Wenlong Qi,1 Lin Tian,2 Jianan Xu,2 Zhenyu Li,2 Tan Wang2 1Changchun University of Traditional Chinese Medicine, Changchun, Jilin, 130000, People’s Republic of China; 2Affiliated Hospital of Changchun University of Traditional Chinese Medicine, Changchun, Jilin, 130000, People’s Republic of ChinaCorrespondence: Tan Wang, The Affiliated Hospital to Changchun University of Chinese Medicine, Changchun, 130021, People’s Republic of China, Email wangtan0215@163.comAbstract: Lung cancer is one of the most lethal malignancies worldwide, making early diagnosis and targeted treatment crucial for improving patient outcomes. Liquid biopsy, a rapidly advancing non-invasive diagnostic tool, has shown significant potential in lung cancer management through dynamic monitoring. This review explores the integration of liquid biopsy with traditional diagnostic techniques in lung cancer management. We first discuss the essential roles of traditional approaches, such as imaging and tissue biopsy, and then examine the concepts of liquid biopsy, emphasizing its unique advantages in early detection, treatment monitoring, and prognosis. Finally, we propose strategies for integrating liquid biopsy with traditional diagnostics, offering multimodal framework to enhance precision medicine in lung cancer.Keywords: liquid biopsy, lung cancer, multimodal diagnosis, ctDNA, CTCs