نبذة مختصرة : Abstract Background Within the realm of medical education, particularly in nursing, the paramount objective is to cultivate professionals who can make optimal clinical decisions through the integration of critical thinking skills, comprehensive knowledge, clinical reasoning, and evidence-based nursing practices. Given that these professional competencies constitute the cornerstone of effective healthcare delivery; their systematic development has become increasingly imperative. This study, therefore, aims to evaluate postgraduate nursing students’ knowledge, attitudes, and performance regarding clinical reasoning and evidence-based nursing. Methods A descriptive cross-sectional multicenter study was undertaken from September through November 2024. The study population comprised postgraduate nursing students from three medical sciences universities in Fars Province, Southern Iran. Through convenience sampling, 165 postgraduate nursing students were enrolled in the study. Data collection was accomplished using two validated questionnaires specifically designed to assess attitudes, knowledge, and performance in clinical reasoning and evidence-based nursing. The comprehensive assessment instrument incorporated three components for clinical reasoning: Clinical Reasoning Attitude (CR-A), Clinical Reasoning Knowledge (CR-K), and Clinical Reasoning Practice (CR-P). Additionally, it included three parallel components for evidence-based nursing: Evidence-Based Nursing Attitude (EBN-A), Evidence-Based Nursing Knowledge (EBN-K), and Evidence-Based Nursing Practice (EBN-P). Statistical analyses were performed using chi-square tests, Kolmogorov-Smirnov test, Pearson correlation coefficients, multiple linear regression with statistical significance established at p
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