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The relationship between cadmium exposure and preeclampsia: a systematic review and meta-analysis

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  • معلومة اضافية
    • بيانات النشر:
      Frontiers Media S.A., 2023.
    • الموضوع:
      2023
    • Collection:
      LCC:Medicine (General)
    • نبذة مختصرة :
      BackgroundCadmium (Cd) is a heavy metal associated with several human disorders. Preeclampsia is a major cause of maternal mortality worldwide. The association between maternal Cd exposure and preeclampsia remains elusive.MethodsTo better understand this relationship, we conducted a systematic review and meta-analysis of eligible studies from five databases (PubMed, Embase, Web of Science, Scopus, and CNKI) from their inception to September 10, 2022. The quality of these studies was evaluated using the Newcastle-Ottawa quality assessment scale (NOS). We use random-effects models to calculate overall standardized mean differences (SMDs) and 95% confidence intervals (CIs). Sensitivity analyses were performed to assess the robustness of our results. We also evaluated publication bias using Egger’s and Begg’s tests. Additionally, we conducted meta-regression and sub-group analyses to identify potential sources of heterogeneity between studies.ResultsOur analysis included a total of 17 studies with 10,373 participants. We found a significant association between maternal cadmium exposure and the risk of preeclampsia (SMD 0.27, 95% CI 0.09–0.44, p
    • File Description:
      electronic resource
    • ISSN:
      2296-858X
    • Relation:
      https://www.frontiersin.org/articles/10.3389/fmed.2023.1259680/full; https://doaj.org/toc/2296-858X
    • الرقم المعرف:
      10.3389/fmed.2023.1259680
    • الرقم المعرف:
      edsdoj.1d77f7dbe3a04e9f829f7ede4cb2c331