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Foveal slope measurements in subjects with high-risk of age-related macular degeneration

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  • معلومة اضافية
    • بيانات النشر:
      Wolters Kluwer Medknow Publications, 2013.
    • الموضوع:
      2013
    • Collection:
      LCC:Ophthalmology
    • نبذة مختصرة :
      Background: Recent reports indicated that the slope of the foveal depression influences the macular pigment (MP) spatial profile. MP has been shown to confer possible protection against age-related macular degeneration (ARMD) because of its antioxidant properties. Aims: To study the configuration of foveal slope and the foveal thickness in fellow eyes of subjects with unilateral neovascular ARMD. Settings and design: Case-control series. Materials and Methods: The study population consisted of 30 cases aged >50, who had unilateral choroidal neovascular membrane (CNVM) or disciform scar in the fellow eye and 29 controls aged >50, who had no sign of ARMD in the either eye. Using spectral-domain optical coherence tomography, foveal thickness at different locations including the central subfield foveal thickness (CSFT) was noted. The foveal slopes were calculated in the six radial scans (between 0.25° and 1° retinal eccentricity) as well as the 3D scan. Results: Cases had a significantly higher CSFT when compared to controls (215.1 ± 36.19 μ vs. 193.0 ± 17.38 μ, P = 0.004). On the 3D scan, the cases had shallower superior (cases 1.32 ± 0.32 vs. controls 1.45 ± 0.13, P = 0.04) and temporal slopes (cases 1.27 ± 0.21 vs. controls 1.39 ± 0.12, P = 0.01) in comparison to the controls. Conclusions: We noted a shallower superior and temporal foveal slope and a higher CSFT in the fellow eyes of subjects with a unilateral neovascular ARMD. Prospective studies observing the development of CNVM in subjects with altered foveal slope might provide more information on this optical coherence tomography finding.
    • File Description:
      electronic resource
    • ISSN:
      0301-4738
      1998-3689
    • Relation:
      http://www.ijo.in/article.asp?issn=0301-4738;year=2013;volume=61;issue=9;spage=507;epage=510;aulast=Raman; https://doaj.org/toc/0301-4738; https://doaj.org/toc/1998-3689
    • الرقم المعرف:
      10.4103/0301-4738.119437
    • الرقم المعرف:
      edsdoj.1d444a16a634bcea57f91af7dc62c0c