Effect of 12 Weeks TRX on Irisin and Chemerin Levels, Fat Percentage, and Body Weight in Older Men: A Clinical Trial

Background and Aims Adipokines have a major role in aging pathobiology and age-related diseases. The present study aims to evaluate the effect of 12 weeks TRX on irisin and chemerin levels in older men. Methods In this randomized clinical trial, 16 older men (Mean age=62.06±1.53 years) were selected using a convenience sampling method and randomly divided into training and control groups. The training group performed TRX for 12 weeks, three sessions per week, each for 60 minutes. The training intensity was evaluated by the Borg rating of perceived exertion scale. Blood sampling was done 24 hours before and after training to measure irisin and chemerin levels. Statistical analysis was done by ANCOVA. The significant level was set at 0.05. Results In the training group, there were significant differences between pre- and post-test levels of irisin (P=0.001) and chemerin (P=0.001). The ANCOVA results showed a significantly higher level of irisin (P=0.001) a lower level of chemerin (P=0.001) in training group than in the control group. Also, the percentage of body fat and weight of people decreased significantly (P=0.001). Conclusion It seems that TRX, by increasing irisin level and reducing chemerin level, can lead to improvement in body fat percentage, weight, and Body Mass Index (BMI) of older men.