Observation of Glomerular Filtration Change in Chronic Hepatitis B Patients Using Tenofovir Disoproxil Fumarate

INTRODUCTION: This study was conducted to assess kidney function tests in outpatient individuals with a diagnosis of chronic hepatitis B who were receiving treatment with Tenofovir Disoproxil Fumarate (TDF). METHODS: Our study included patients who presented to the Infectious Diseases Polyclinic at XXX Hospital with a diagnosis of chronic hepatitis B (CHB) and were treated with Tenofovir Disoproxil Fumarate (TDF). The hospital data, available retrospectively since 2013, allowed us to examine patient follow-ups up to that year. As a result, we were able to analyze a maximum follow-up period of nine years. The study encompassed individuals over 18 years of age whose data were complete and who were regularly monitored in the outpatient clinic. RESULTS: Among the subjects, 69% (n: 69) were male, and 31% (n: 31) were female. Significant reductions in glomerular filtration rates (GFR) were observed in the 4th and 6th years compared to GFR measurements before initiating TDF treatment (p