Prediction of Vitamin D and Serotonin levels with increased risk Depressive in Adolescent Students

Vitamin D deficiency (Vt.D) is common in adolescents and is influenced by some factors, including puberty. It impacted serotonin levels, thus increasing the risk of depression. This study was conducted to assess the association between vitamin D deficiency and depression and its effect on adolescent students. A cross-sectional study of 130 adolescent students aged 12-18 years, between November 2023 to February 2024. This study investigated serum Vt.D, serotonin levels, and hematological indices such as (RBC, Hb, MCV, and MCH, of adolescents, in addition, it was dependent on the Beck Depression Inventory to calculate scales of depression. 130 adolescent students were enrolled aged 12-18, mean ± SD: 14.85±2.19. The results indicated that 77(59.2%) students had depression symptoms, median (IQR) of scores16(13₋21.5), and 53(40.8%) adolescents with non-depressed (scores 5(2.5₋7), who were considered as the control group, a statistically significant between these groups (p=0.035). Depression was significantly more prevalent in females 46(59.7%) than males 31(40.3%), p=0.014. Deficiency Vt.D was found in 63.6% of the total depressive adolescents and was significantly more than nondepressive adolescents 3.8%, p