نبذة مختصرة : Objective To assess the effects of dimethicone at different doses in bowel preparation for small bowel capsule endoscopy (SBCE) and explore the optimal dose for the examination. Methods A multicenter randomized controlled trial (RCT) was carried out on 132 patients from 4 different institutions from May 2016 to January 2019. They were randomly divided into 3 groups, with 44 cases in each group. All of them were given 2 liters of polyethylene glycol (PEG) solution orally 6 h before procedure, and then in 30 min before examination, the patients were asked to drink 100 mL pure water, 2.5 g and 5 g 100 mL dimethicone solution for those from group A, B and C, respectively. The primary evaluation indexes included small bowel bubble quantity (SBBQ), small bowel valid picture ratio (SBVPR), small bowel cleaning quality (SBCQ), and the secondary evaluation indexes contained gastric bubble quantity (GBQ), gastric cleaning quality (GCQ), completion rate (CR), diagnostic yield (DY), and small bowel transit time (SBTT) and gastric transit time(GTT) of the capsule. Results The SBBQ of group A was higher than those of the other 2 groups in the proximal, middle and distal segments of small intestine (P0.05). Similar results were seen in the SBIRP in the 3 groups. No statistical significances were found in other indexes among the 3 groups (P>0.05). Conclusion Dimethicone treatment can efficiently decrease intraluminal bubbles and improve the visibility of small bowel mucosa for SBCE, and the optimal dose of dimethicone is 2.5 g.
Processing Request
No Comments.