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CeLL CyCLe NeWS & VieWS 1018 Cell Cycle Volume 12 issue 7 Cell Cycle News & Views

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اقرأ أكثر حفظ في قائمتي
  • المؤلفون: Vitamin D
  • المصدر:
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3646856/pdf/cc-12-1019.pdf?origin%3Dpublication_detail.
  • نوع التسجيلة:
    text
  • اللغة:
    English
  • معلومة اضافية
    • Contributors:
      The Pennsylvania State University CiteSeerX Archives
    • الموضوع:
      1018
    • Collection:
      CiteSeerX
    • نبذة مختصرة :
      Already in the eighties it was shown that the active form of vitamin D3, 1,25-dihydroxyvi-tamin D3 [1,25(OH)2D3], can inhibit the pro-liferation of melanoma cells1 and stimulate the differentiation of myeloid leukemia cells.2 The almost universal presence of the vita-min D receptor (VDR) and the presence of 1α-hydroxylase (CyP27B1) activity in non-clas-sical tissues together with the antiproliferative and prodifferentiating effects suggests a para-crine role for 1,25(OH)2D3. 1,25(OH)2D3 directly regulates the expression of a whole set of genes through binding to the VDR which het-erodimerizes to the retinoid X receptor (RXR), and 1,25(OH)2D3-VDR/RXR complexes bind to
    • File Description:
      application/pdf
    • Relation:
      http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.657.9276; http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3646856/pdf/cc-12-1019.pdf?origin%3Dpublication_detail
    • Rights:
      Metadata may be used without restrictions as long as the oai identifier remains attached to it.
    • الرقم المعرف:
      edsbas.FEB85668