Contributors: Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS San Raffaele Pisana); Ospedale Policlinico San Martino Genoa; University of Copenhagen = Københavns Universitet (UCPH); Universidad de Navarra Pamplona (UNAV); Instituto de Investigación Sanitaria de Navarra Pamplona, Spain (IdiSNA); Institute for Medical Research and Occupational Health; Norwegian Institute of Public Health Oslo (NIPH); School of Nutrition and Translational Research in Metabolism Maastricht (NUTRIM); Maastricht University Maastricht; Flemish Institute for Technological Research (VITO); Instituto Nacional de Saùde Dr Ricardo Jorge Portugal (INSA); Universidade Luterana do Brasil - ULBRA (BRAZIL); Universidade Luterana do Brasil (ULBRA); Istituto Nazionale per l’Assicurazione contro gli Infortuni sul Lavoro Italian Workers Compensation Authority (INAIL); NEUROFARBA Department Firenze, Italy; Università degli Studi di Firenze = University of Florence = Université de Florence (UniFI); Università degli Studi di Milano = University of Milan (UNIMI); IRCCS San Raffaele Scientific Institute Milan, Italie; National Institute of Public Health - National Institute of Hygiene Poland; N.N. Blokhin National Medical Research Center of Oncology; Slovak Medical University of Bratislava (SMU); Slovak Academy of Science Bratislava (SAS); University of A Coruña (UDC); Instituto de Investigación Biomédica de A Coruña La Corogne, Espagne (INIBIC); A Coruña University Hospital La Corogne, Espagne; Universitat Autònoma de Barcelona = Autonomous University of Barcelona = Universidad Autónoma de Barcelona (UAB); Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública = Consortium for Biomedical Research of Epidemiology and Public Health (CIBERESP); School of Medecine Belgrade; University of Belgrade Belgrade; Contaminants & Stress Cellulaire (ToxAlim-COMICS); ToxAlim (ToxAlim); Université Toulouse III - Paul Sabatier (UT3); Université de Toulouse (UT)-Université de Toulouse (UT)-Ecole Nationale Vétérinaire de Toulouse (ENVT); Institut National Polytechnique (Toulouse) (Toulouse INP); Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP); Université de Toulouse (UT)-Ecole d'Ingénieurs de Purpan (INP - PURPAN); Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Toulouse III - Paul Sabatier (UT3); Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE); Centre de recherche en épidémiologie et santé des populations (CESP); Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay; Unité de recherche interdisciplinaire pour la prévention et le traitement des cancers (ANTICIPE); Université de Caen Normandie (UNICAEN); Normandie Université (NU)-Normandie Université (NU)-CHU Caen; Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN)-Centre Régional de Lutte contre le Cancer François Baclesse Caen (UNICANCER/CRLC); Normandie Université (NU)-UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN)-UNICANCER-Institut National de la Santé et de la Recherche Médicale (INSERM); Instituto de Ciencias Básicas y Preclínicas Victoria de Girón; Hacettepe University = Hacettepe Üniversitesi; National center for public health Hungary; Norwegian Institute for Air Research (NILU); University of Oslo (UiO); This article is based upon work from COST Action CA15132 (hCOMET), supported by COST (European Cooperation in Science and Technology). The work of SB and PR was supported by funds granted by the Italian Ministry of Health for Institutional Research (Ricerca Corrente).
نبذة مختصرة : International audience ; Abstract The comet assay or single cell gel electrophoresis, is the most common method used to measure strand breaks and a variety of other DNA lesions in human populations. To estimate the risk of overall mortality, mortality by cause, and cancer incidence associated to DNA damage, a cohort of 2,403 healthy individuals (25,978 person-years) screened in 16 laboratories using the comet assay between 1996 and 2016 was followed-up. Kaplan–Meier analysis indicated a worse overall survival in the medium and high tertile of DNA damage (p < 0.001). The effect of DNA damage on survival was modelled according to Cox proportional hazard regression model. The adjusted hazard ratio (HR) was 1.42 (1.06–1.90) for overall mortality, and 1.94 (1.04–3.59) for diseases of the circulatory system in subjects with the highest tertile of DNA damage. The findings of this study provide epidemiological evidence encouraging the implementation of the comet assay in preventive strategies for non-communicable diseases.
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