Item request has been placed! ×
Item request cannot be made. ×
loading  Processing Request

Associations between fruit, vegetable and legume intakes and prostate cancer risk: results from the prospective Supplémentation en Vitamines et Minéraux Antioxydants (SU.VI.MAX) cohort

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
  • معلومة اضافية
    • Contributors:
      Equipe 3: EREN- Equipe de Recherche en Epidémiologie Nutritionnelle (CRESS - U1153); Université Paris 13 (UP13)-Institut National de la Recherche Agronomique (INRA)-Conservatoire National des Arts et Métiers CNAM (CNAM)-Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)); Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM); Hôpital Avicenne AP-HP; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)
    • بيانات النشر:
      HAL CCSD
      Cambridge University Press (CUP)
    • الموضوع:
      2016
    • Collection:
      Institut National de la Recherche Agronomique: ProdINRA
    • نبذة مختصرة :
      International audience ; Although experimental studies suggest that fruits, vegetables and legumes may exert protective effects against prostate carcinogenesis through various bioactive compounds such as dietary fibre and antioxidants, epidemiological evidence is lacking. Notably, very few prospective studies have investigated the relationship between legume intake and prostate cancer risk. Our objective was to prospectively investigate the association between fruit, vegetable, tomato products, potatoes and legume intakes and prostate cancer risk. This study included 3313 male participants to the SUpplémentation en VItamines et Minéraux AntioXydants cohort (follow-up: 1994-2007) who completed at least three 24-h dietary records during the first 2 years of follow-up. Associations between tertiles of intake and prostate cancer risk were assessed by multivariate Cox proportional hazards models. After a median follow-up of 12·6 years, 139 incident prostate cancers were diagnosed. An inverse association was observed between prostate cancer risk and tertiles of legume intake (hazard ratio (HR) T3v.T1 = 0·53; 95 % CI 0·34, 0·85; P trend = 0·009). This association was maintained after excluding soya and soya products from the legume group (HR T3 v.T1 = 0·56; 95 % CI 0·35, 0·89; P trend = 0·02). No association was observed between prostate cancer risk and tertiles of intakes of fruits (P trend = 0·25), vegetables (P trend = 0·91), potatoes (P trend = 0·77) and tomato products (P trend = 0·09). This prospective study confirms the null association between fruit and non-starchy vegetable intakes and prostate cancer risk observed in most previous cohorts. In contrast, although very few prospective studies have been published on the topic, our results suggest an inverse association between legume intake and prostate cancer risk, supported by mechanistic plausibility. These results should be confirmed by large-scale observational and intervention studies.
    • Relation:
      info:eu-repo/semantics/altIdentifier/pmid/26950824; hal-02438756; https://hal.science/hal-02438756; https://hal.science/hal-02438756/document; https://hal.science/hal-02438756/file/associations_between_fruit_vegetable_and_legume_intakes_and_prostate_cancer_risk_results_from_the_prospective_supplementation_en_vitamines_et_mineraux_antioxydants_suvimax_cohort.pdf; PRODINRA: 354437; PUBMED: 26950824; WOS: 000376673700009
    • الرقم المعرف:
      10.1017/S0007114516000520
    • الدخول الالكتروني :
      https://hal.science/hal-02438756
      https://hal.science/hal-02438756/document
      https://hal.science/hal-02438756/file/associations_between_fruit_vegetable_and_legume_intakes_and_prostate_cancer_risk_results_from_the_prospective_supplementation_en_vitamines_et_mineraux_antioxydants_suvimax_cohort.pdf
      https://doi.org/10.1017/S0007114516000520
    • Rights:
      info:eu-repo/semantics/OpenAccess
    • الرقم المعرف:
      edsbas.FD7889BB