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Transcatheter aortic valve implantation in patients with uninterrupted vitamin K antagonists

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اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • Contributors:
      Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier); Centre Hospitalier Universitaire de Nîmes (CHU Nîmes); Physiologie & médecine expérimentale du Cœur et des Muscles U 1046 (PhyMedExp); Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM); Initial MAnagement and prevention of acute orGan failures IN critically ill patiEnts (IMAGINE); Université de Montpellier (UM); Biomécanique des Interactions et de l'Organisation des Tissus et des Cellules (BIOTIC); Laboratoire de Mécanique et Génie Civil (LMGC); Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM); Institut de Génomique Fonctionnelle (IGF); Clinique du Millénaire - Oc Santé Montpellier; Oc Santé Montpellier
    • بيانات النشر:
      HAL CCSD
      Wiley
    • الموضوع:
      2022
    • Collection:
      Archive ouverte HAL (Hyper Article en Ligne, CCSD - Centre pour la Communication Scientifique Directe)
    • نبذة مختصرة :
      International audience ; Background: Bridging of vitamin K antagonist (VKA) with heparin is usually not promoted during interventional or surgical procedures related to increased risk of bleeding and thrombotic events but this strategy has not been evaluated during transcatheter aortic valve implantation (TAVI).Purpose: The aim of this study was to evaluate the rate of major bleeding and vascular complications after TAVI performed in patients with uninterrupted VKA.Methods: From January 2016 to October 2017, consecutive patients who underwent TAVI with uninterrupted VKA (International Normalized Ratio [INR] between 1.5 and 3.5) were prospectively included in a monocentric registry. TAVI was performed according to current guidelines and a 50 U/kg bolus of heparin was injected at the beginning of the procedure for all patients. Vascular and bleeding complications were assessed using the Valve Academic Research Consortium 3 (VARC3) and the Bleeding Academic Research Consortium (BARC) definitions at a 30-day follow-up.Results: A total of 88 patients were included with a median age of 84 years (81.8-87.0), 42% being female. The median society of thoracic surgeons score was 5.1 (4.1-7.5), the median CHADS2-VASc was 5.5 (5-6) and 60.2% had a chronic kidney failure. Median INR at the time of implantation was 2.1 (1.8-2.6). The main VKA indication was atrial fibrillation. Transfemoral access was used in 88.6% of the patients. Major bleeding (BARC ≥ 3b) occurred in five patients (5.7%) and major vascular complications occurred in seven patients (8.0%). At 1 month follow-up, major bleeding (BARC ≥ 3) or vascular complications occurred in 10 patients (11.4%). In patients with major bleeding peripheral arterial disease (RR = 10.95; 95% confidence interval (CI) 1.63-73.75; p = 0.014) and carotid access (RR = 8.56; 95% CI 1.19-1.51; p = 0.033) were more common. INR > 2.5 was significantly associated with vascular complications (RR = 7.14; 95% CI 1.29-39.63; p = 0.025). At 30 days, mortality and stroke rates were 2.3% and ...
    • Relation:
      info:eu-repo/semantics/altIdentifier/pmid/35661552; hal-04083488; https://hal.science/hal-04083488; https://hal.science/hal-04083488/document; https://hal.science/hal-04083488/file/2022%20Robert%20et%20al%20Transcatheter%20aortic%20valve.pdf; PUBMED: 35661552; WOS: 000806115300001
    • الرقم المعرف:
      10.1002/ccd.30248
    • Rights:
      info:eu-repo/semantics/OpenAccess
    • الرقم المعرف:
      edsbas.FB9CB183