Contributors: Gabani, Rami; Spione, Francesco; Arevalos, Victor; Grima Sopesens, Nadine; Ortega-Paz, Lui; Gomez-Lara, Josep; Jimenez-Diaz, Victor; Jimenez, Marcelo; Jiménez-Quevedo, Pilar; Diletti, Roberto; Pineda, Javier; Campo, Gianluca; Silvestro, Antonio; Maristany, Jaume; Flores, Xacobe; Oyarzabal, Loreto; Bastos-Fernandez, Guillermo; Iñiguez, André; Serra, Antonio; Escaned, Javier; Ielasi, Alfonso; Tespili, Maurizio; Lenzen, Mattie; Gonzalo, Nieve; Bordes, Pascual; Tebaldi, Matteo; Biscaglia, Simone; Al-Shaibani, Soheil; Romaguera, Rafael; Gomez-Hospital, Joan Antoni; Rodes-Cabau, Josep; Serruys, Patrick W; Sabaté, Manel; Brugaletta, Salvatore
نبذة مختصرة : BACKGROUND Short-term outcomes following ST-segment elevation myocardial infarction (STEMI) in women are worse than in men, with a higher mortality rate. It is unknown whether sex plays a role in very long term outcomes. OBJECTIVES The aim of this study was to assess whether very long term outcomes following STEMI treatment are influenced by sex. METHODS EXAMINATION-EXTEND (10-Year Follow-Up of the EXAMINATION Trial) was an investigator-driven 10-year follow-up of the EXAMINATION (A Clinical Evaluation of Everolimus Eluting Coronary Stents in the Treatment of Patients With ST-Segment Elevation Myocardial Infarction) trial, which randomly 1:1 assigned 1,498 patients with STEMI to receive either everolimus-eluting stents or bare-metal stents. The present study was a subanalysis according to sex. The primary endpoint was the composite patient-oriented endpoint (all-cause death, any myocardial infarction, or any revasculari-zation) at 10 years. Secondary endpoints were individual components of the primary endpoint. All endpoints were adjusted for age. RESULTS Among 1,498 patients with STEMI, 254 (17%) were women. Overall, women were older, with more arterial hypertension and less smoking history than men. At 10 years, no difference was observed between women and men for the patient-oriented composite endpoint (40.6% vs 34.2%; adjusted HR: 1.14; 95% CI: 0.91-1.42; P = 0.259). There was a trend toward higher all-cause death in women vs men (27.6% vs 19.4%; adjusted HR: 1.30; 95% CI: 0.99-1.71; P = 0.063), with no difference in cardiac death or other endpoints. CONCLUSIONS At very long term follow-up, there were no differences in the combined patient-oriented endpoint between women and men, with a trend toward higher all-cause death in women not driven by cardiac death. The present findings underline the need for focused personalized medicine in women after percutaneous revascularization aimed at both cardiovascular and sex-specific risk factor control and targeted treatment. (10-Years Follow-Up of the EXAMINATION ...
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