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Relationship between Exercise Intensity and IL-6 Increase during an 80 km Long-Distance Running Race

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  • معلومة اضافية
    • Contributors:
      Centre de recherche en épidémiologie et santé des populations (CESP); Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay; Hôpital Ambroise Paré AP-HP; Institut de recherche biomédicale et d’épidémiologie du sport (IRMES - URP_7329); Institut national du sport, de l'expertise et de la performance (INSEP)-Université Paris Cité (UPCité); National Cystic Fibrosis Reference Center CHU Necker (CNR - INSERM U1151); Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Necker - Enfants Malades AP-HP; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP); Université Paris Cité (UPCité); Service Néphrologie et transplantation rénale Adultes CHU Necker; Hôpital Necker - Enfants Malades AP-HP; Service de cardiologie et maladies vasculaires CHU Ambroise Paré; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Ambroise Paré AP-HP; Université de Versailles Saint-Quentin-en-Yvelines - UFR Sciences de la santé Simone Veil (UVSQ Santé); Université de Versailles Saint-Quentin-en-Yvelines (UVSQ); Centre d'Investigation en Médecine du sport (CIMS); Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôtel-Dieu
    • بيانات النشر:
      HAL CCSD
      MDPI
    • الموضوع:
      2022
    • Collection:
      Université de Versailles Saint-Quentin-en-Yvelines: HAL-UVSQ
    • نبذة مختصرة :
      International audience ; Background: IL-6 plasma concentration (IL-6PC) reflects the systemic inflammation related to exercise intensity level. This study aims to describe the IL-6PC kinetics during a long-distance running race. IL-6PC was measured in 20 male runners before (0 km), at each refreshment point (at 21 and 53 km, i.e., k21 and k53, respectively) and at the end of an 80 km long-distance run (k80).Methods: IL-6PC variations (absolute and relative values in each of the three sections (S)) were calculated over S1 (0_k21), S2 (k21_k53) and S3 (k53_k80) and compared with the exercise intensity (duration*race speed) within each section.Results: The mean IL-6PC increased during the run: 2.1 ± 0.6 ng.L−1 at 0 km, 21.0 ± 11.3 ng.L−1 at k21, 38.9 ± 13.0 ng.L−1 at k53 and 49.8 ± 11.9 ng.L−1 at k80 . Exercise intensity increased between S1 (24.2 ± 0.5) and S2 (51.9 ± 3.2) (p = 0.04) but not between S2 and S3 (67.4 ± 4.5) (p = 0.69). IL-6PC variation was associated with exercise intensity within S1 (p = 0.03) and S2 (p = 2 × 10−3 ) and showed at least a trend within S3 (p = 0.06).Conclusions: IL-6PC increases that occur during the early stages of a long-distance run are associated with the running intensity, and then IL-6PC remain stable after the reduction in intensity related to the decrease in running speed.
    • Relation:
      info:eu-repo/semantics/altIdentifier/pmid/35681953; hal-03775056; https://hal.science/hal-03775056; https://hal.science/hal-03775056/document; https://hal.science/hal-03775056/file/ijerph-19-06368.pdf; PUBMED: 35681953
    • الرقم المعرف:
      10.3390/ijerph19116368
    • Rights:
      http://creativecommons.org/licenses/by/ ; info:eu-repo/semantics/OpenAccess
    • الرقم المعرف:
      edsbas.FB4527C5