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Bioelectronic cell-based device provides a strategy for the treatment of the experimental model of multiple sclerosis

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اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • بيانات النشر:
      Elsevier
    • الموضوع:
      2022
    • Collection:
      ETH Zürich Research Collection
    • نبذة مختصرة :
      Wireless powered optogenetic cell-based implant provides a strategy to deliver subcutaneously therapeutic proteins. Immortalize Human Mesenchymal Stem Cells (hMSC-TERT) expressing the bacteriophytochrome diguanylate cyclase (DGCL) were validated for optogenetic controlled interferon-β delivery (Optoferon cells) in a bioelectronic cell-based implant. Optoferon cells transcriptomic profiling was used to elaborate an in-silico model of the recombinant interferon-β production. Wireless optoelectronic device integration was developed using additive manufacturing and injection molding. Implant cell-based optoelectronic interface manufacturing was established to integrate industrial flexible compact low-resistance screen-printed Near Field Communication (NFC) coil antenna. Optogenetic cell-based implant biocompatibility, and device performances were evaluated in the Experimental Autoimmune Encephalomyelitis (EAE) mouse model of multiple sclerosis. ; ISSN:0168-3659 ; ISSN:1873-4995
    • File Description:
      application/application/pdf
    • Relation:
      info:eu-repo/semantics/altIdentifier/wos/000893242000002; info:eu-repo/grantAgreement/SBFI/H2020/720694; http://hdl.handle.net/20.500.11850/582983
    • الرقم المعرف:
      10.3929/ethz-b-000582983
    • الدخول الالكتروني :
      https://hdl.handle.net/20.500.11850/582983
      https://doi.org/10.3929/ethz-b-000582983
    • Rights:
      info:eu-repo/semantics/openAccess ; http://creativecommons.org/licenses/by-nc-nd/4.0/ ; Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
    • الرقم المعرف:
      edsbas.F9E25B4