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Flocculation in Saccharomyces cerevisiae is regulated by RNA/DNA helicase Sen1p

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اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • Contributors:
      Council of Scientific and Industrial Research; Department of Biotechnology
    • بيانات النشر:
      Wiley
    • الموضوع:
      2015
    • Collection:
      Wiley Online Library (Open Access Articles via Crossref)
    • نبذة مختصرة :
      The Nrd1–Nab3–Sen1 (NNS) complex terminates transcription of non‐coding RNA genes and mediates degradation of the produced transcript by the nuclear exosome. The NNS complex also represses some stress response genes, by stimulating premature termination. A well‐characterized stress response in yeast is flocculation, where cells aggregate to form flocs under expression of lectin‐encoding genes designated as FLOs. In this study, we demonstrated the role of the NNS complex and Rrp6p in the expression of flocculation genes: FLO1 , FLO5 , FLO9 , and FLO10 . Furthermore, a deletion mutant of the RNA processing machinery ( RNT1 ), and SEN1 mutants that are unable to interact with Rnt1p, exhibit a flocculation phenotype. In summary, we have identified a cooperative role of Rnt1p, Rrp6p and the NNS complex in the repression of FLO genes.
    • الرقم المعرف:
      10.1016/j.febslet.2015.09.006
    • الدخول الالكتروني :
      https://doi.org/10.1016/j.febslet.2015.09.006
      http://dx.doi.org/10.1016/j.febslet.2015.09.006
      https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1016%2Fj.febslet.2015.09.006
      https://febs.onlinelibrary.wiley.com/doi/pdf/10.1016/j.febslet.2015.09.006
    • Rights:
      http://onlinelibrary.wiley.com/termsAndConditions#vor
    • الرقم المعرف:
      edsbas.F7D249E