The Association between CETP (rs5882) gene polymorphism and optic neuritis

Background. Optic Neuritis (ON) is defined as inflammation of the optic nerve, which is mostly idiopathic. However it can be associated with variable causes (demyelinating lesions, autoimmune disorders, infectious and inflammatory conditions). Inflammatory demyelinating disorder of the optic nerve is which can be associated with multiple sclerosis. It is thought that the CETP gene plays a key role in this autoimmune inflammatory disease. Aim. The aim of our study was to determine if the frequency of the CETP rs5882 gene polymorphism have an influence on the development of acute optic neuritis. Materials and methods. Study participants comprised of 50 patients with a diagnosis of optic neuritis, and 808 subjects from the reference group. The genotyping test of CETP rs5882 polymorphism was carried out using the real-time polymerase chain reaction (RT-PCR) method. Results. CETP rs5882 gene polymorphism analysis in the overall group has not revealed any differences in the distribution of G/G, G/A, and A/A genotypes between patients with ON and control group was 9.65%, 42.70% and 47.65% vs. 12%, 52% and 36%, respectively, p=0.277. Conclusion. CETP rs5882 gene polymorphism had no predominant effect on the development of optic neuritis.