Hedonic judgments of chemical compounds are correlated with molecular size

Different psychophysical works have reported that, when a wide range of odors is assessed, the hedonic dimension is the most salient. Hence, pleasantness is the most basic attribute of odor perception. Recent studies suggest that the molecular size of a given odorant is positively correlated with its hedonic character. This correlation was confirmed in the present study, but further basic molecular features affecting pleasantness were identified by means of multiple linear regression for the compounds contained in five chemical sets. For three of them, hedonic judgments are available in the literature. For a further two chemical sets, hedonic scores were estimated from odor character descriptions based on numerical profiles. Generally speaking, fairly similar equations were obtained for the prediction of hedonic judgments in the five chemical sets, with R 2 values ranging from 0.46 to 0.71. The results suggest that larger molecules containing oxygen are more likely to be perceived as pleasant, while the opposite applies to carboxylic acids and sulfur compounds. © 2011 by the authors; licensee MDPI, Basel, Switzerland. ; Zarzo Castelló, M. (2011). Hedonic judgments of chemical compounds are correlated with molecular size. Sensors. 11(4):3667-3686. doi:10.3390/s110403667 ; S ; 3667 ; 3686 ; 11 ; 4 ; Doleman, B. J., Severin, E. J., & Lewis, N. S. (1998). Trends in odor intensity for human and electronic noses: Relative roles of odorant vapor pressure vs. molecularly specific odorant binding. Proceedings of the National Academy of Sciences, 95(10), 5442-5447. doi:10.1073/pnas.95.10.5442 ; Zarzo, M. (2007). The sense of smell: molecular basis of odorant recognition. Biological Reviews, 82(3), 455-479. doi:10.1111/j.1469-185x.2007.00019.x ; Haddad, R., Medhanie, A., Roth, Y., Harel, D., & Sobel, N. (2010). Predicting Odor Pleasantness with an Electronic Nose. PLoS Computational Biology, 6(4), e1000740. doi:10.1371/journal.pcbi.1000740 ; A. L. Williams, P. H. Heinemann, C. J. Wysocki, D. M. Beyer, & R. E. ...