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Verification that common variation at 2q37.1, 6p25.3, 11q24.1, 15q23, and 19q13.32 influences chronic lymphocytic leukaemia risk

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اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • Contributors:
      Cancer Genetics; Insitute of Cancer Research; Genetics and Pathology; Uppsala University; Hematopathology Unit; University of Barcelona; Genomic Medicine Group; University of Santiago de Compostela; Department of Medicine; Clinical Epidemiology; Department of Hematology; Leukemia Laboratory; Hematology and Transplantation; Lund Strategic Research Center for Stem Cell Biology and Cell Therapy; Department of Haematology; Haemato-oncology; Institute of cancer research; Department of Pathology; Hospital Clínic of Barcelona; Dept of Genetics and Pathology; 15 Cotswold Road; Haddow Laboratories
    • بيانات النشر:
      HAL CCSD
      Wiley
    • الموضوع:
      2010
    • Collection:
      Archive ouverte HAL (Hyper Article en Ligne, CCSD - Centre pour la Communication Scientifique Directe)
    • نبذة مختصرة :
      International audience ; A recent genome wide association study of chronic lymphocytic leukemia (CLL) has provided evidence that common variation at 2q13 (rs17483466), 2q37.1 (rs13397985), 6p25.3 (rs872071), 11q24.1 (rs735665), 15q23 (rs7176508) and 19q13.32 (rs11083846) affects CLL risk. To verify and further explore the relationship between these variants and CLL risk we genotyped case-control datasets from Spain and Sweden totaling 824 cases and 850 controls. Combined data provided statistically significant support for an association between genotypes at rs13397985, rs872071, rs735665, rs7176508 and rs11083846 and CLL risk. CLL risk was shown to increase with increasing numbers of risk alleles (Ptrend=1.40x10-15), consistent with a polygenic model of disease susceptibility. These data validate the relationship between common variation and risk of CLL.
    • Relation:
      hal-00552600; https://hal.archives-ouvertes.fr/hal-00552600; https://hal.archives-ouvertes.fr/hal-00552600/document; https://hal.archives-ouvertes.fr/hal-00552600/file/PEER_stage2_10.1111%252Fj.1365-2141.2010.08270.x.pdf
    • الرقم المعرف:
      10.1111/j.1365-2141.2010.08270.x
    • Rights:
      info:eu-repo/semantics/OpenAccess
    • الرقم المعرف:
      edsbas.F57C76B9