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Occupational exposure to pesticides and lymphoid neoplasms among men: results of a French case-control study.

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اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • Contributors:
      Epidémiologie environnementale des cancers; Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Santé et de la Recherche Médicale (INSERM); Occupational Health Department; French institute of Public Health; Plateforme de génétique moléculaire des cancers d'Aquitaine; Institut Bergonié Bordeaux; UNICANCER-UNICANCER; Registre des hémopathies malignes de la Gironde; Les instituts techniques agricoles (Acta); Service d'Hématologie; Hôpital Morvan Brest; Service d'hématologie clinique Avicenne; Université Paris 13 (UP13)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Avicenne AP-HP; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP); Service des maladies du sang; CHU Bordeaux-Hôpital Haut-Lévêque CHU Bordeaux; CHU Bordeaux-Groupe Hospitalier Sud Ile-de-France (GHSIF); Service Hématologie - IUCT-Oncopole CHU Toulouse; Pôle Biologie CHU Toulouse; Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Pôle IUCT CHU Toulouse; Centre Hospitalier Universitaire de Toulouse (CHU Toulouse); Laboratoire d'Hématologie Biologique CHU Caen; Université de Caen Normandie (UNICAEN); Normandie Université (NU)-Normandie Université (NU)-CHU Caen; Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN)
    • بيانات النشر:
      HAL CCSD
    • الموضوع:
      2009
    • Collection:
      Université Paris 13: HAL
    • نبذة مختصرة :
      International audience ; OBJECTIVES: Investigating the relationship between occupational exposure to pesticides and the risk of lymphoid neoplasms (LNs) in men. METHODS: A hospital-based case-control study was conducted in six centres in France between 2000 and 2004. The cases were incident cases with a diagnosis of LN aged 18-75 years. During the same period, controls of the same age and sex as the cases were recruited in the same hospital, mainly in the orthopaedic and rheumatological departments. Exposures to pesticides were evaluated through specific interviews and case-by-case expert reviews. Four hundred and ninety-one cases (244 cases of non-Hodgkin's lymphoma (NHL), 87 of Hodgkin's lymphoma (HL), 104 of lymphoproliferative syndromes (LPSs) and 56 of multiple myeloma (MM) cases) and 456 controls were included in the analyses. The odds ratios (ORs) and 95% CI were estimated using unconditional logistic regressions. RESULTS: Positive associations between HL and occupational exposure to triazole fungicides and urea herbicides were observed (OR = 8.4 (2.2 to 32.4), 10.8 (2.4 to 48.1), respectively). Exposure to insecticides, fungicides and herbicides were linked to a threefold increase in MM risk (OR = 2.8 (1.2 to 6.5), 3.2 (1.4 to 7.2), 2.9 (1.3 to 6.5)). For LPS subtypes, associations restricted to hairy-cell leukaemia (HCL) were evidenced for exposure to organochlorine insecticides, phenoxy herbicides and triazine herbicides (OR = 4.9 (1.1 to 21.2), 4.1 (1.1 to 15.5), 5.1 (1.4 to 19.3)), although based on small numbers. Lastly, despite the increased ORs for organochlorine and organophosphate insecticides, carbamate fungicides and triazine herbicides, no significant associations were evidenced for NHL. CONCLUSIONS: The results, based on case-by-case expert review of occupation-specific questionnaires, support the hypothesis that occupational pesticide exposures may be involved in HL, MM and HCL and do not rule out a role in NHL. The analyses identified specific pesticides that deserve further investigation ...
    • Relation:
      info:eu-repo/semantics/altIdentifier/pmid/19017688; inserm-00342613; https://inserm.hal.science/inserm-00342613; https://inserm.hal.science/inserm-00342613/document; https://inserm.hal.science/inserm-00342613/file/inserm-00342613_edited.pdf; https://inserm.hal.science/inserm-00342613/file/ORSI_OEM_2008.pdf; PRODINRA: 249382; PUBMED: 19017688; WOS: 000265274700003
    • الرقم المعرف:
      10.1136/oem.2008.040972
    • Rights:
      info:eu-repo/semantics/OpenAccess
    • الرقم المعرف:
      edsbas.F42387F3