Associations between peripheral perfusion disorders, mean arterial pressure and dose of norepinephrine administrated in the early phase of septic shock

International audience ; Septic shock is a complex critical condition associated with a reported mortality rate up to 30% to 40%. 1 It is the most severe form of sepsis with concomitant haemodynamic failure and immune, inflammatory and metabolic disorders. The resulting circulatory shock finally leads to an alteration of tissue perfusion causing organ failures and associated poor outcomes. 2,3 Therefore, maintaining organ perfusion in the time course of septic shock is a fundamental goal.