Contributors: Gaudino, M.; Benedetto, U.; Fremes, S.; Ballman, K.; Biondi-Zoccai, G.; Sedrakyan, A.; Nasso, G.; Raman, J.; Buxton, B.; Hayward, P. A.; Moat, N.; Collins, P.; Webb, C.; Peric, M.; Petrovic, I.; Yoo, K. J.; Hameed, I.; Di Franco, A.; Moscarelli, M.; Speziale, G.; Girardi, L. N.; Hare, D. L.; Taggart, D. P.
نبذة مختصرة : It is generally accepted that radial artery (RA) grafts have better mid-term patency rate compared to saphenous vein grafts. However, the clinical correlates of the improved patency rate are still debated. Observational studies have suggested increased survival and event-free survival for patients who receive an RA rather than a saphenous vein, but they are open to bias and confounders. The only evidence based on randomized data is a pooled meta-analysis of 6 randomized controlled trial comparing the RA and the saphenous vein published by the RADial artery International Alliance (RADIAL). In the RADIAL database, improved freedom from follow-up cardiac events (death, myocardial infarction and repeat revascularization) was found at 5-year follow-up in the RA arm. The most important limitation of the RADIAL analysis is that most of the included trials had an angiographic follow-up in the first 5 years and it is unclear whether the rate of repeat revascularization (the main driver of the composite outcome) was clinically indicated due to per-protocol angiographies. Here, we present the protocol for the long-term analysis of the RADIAL database. By extending the follow-up beyond the 5th postoperative year (all trials except 1 did not have angiographic follow-up beyond 5 years), we aim to provide data on the role of RA in coronary artery bypass surgery with respect to long-term outcomes.
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