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Blood-brain barrier transporters: An overview of function, dysfunction in Alzheimer's disease and strategies for treatment

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  • معلومة اضافية
    • بيانات النشر:
      Elsevier B.V.
    • الموضوع:
      2024
    • Collection:
      Queensland University of Technology: QUT ePrints
    • نبذة مختصرة :
      The blood-brain-barrier (BBB) has a major function in maintaining brain homeostasis by regulating the entry of molecules from the blood to the brain. Key players in BBB function are BBB transporters which are highly expressed in brain endothelial cells (BECs) and critical in mediating the exchange of nutrients and waste products. BBB transporters can also influence drug delivery into the brain by inhibiting or facilitating the entry of brain targeting therapeutics for the treatment of brain disorders, such as Alzheimer's disease (AD). Recent studies have shown that AD is associated with a disrupted BBB and transporter dysfunction, although their roles in the development in AD are not fully understand. Modulation of BBB transporter activity may pose a novel approach to enhance the delivery of drugs to the brain for enhanced treatment of AD. In this review, we will give an overview of key functions of BBB transporters and known changes in AD. In addition, we will discuss current strategies for transporter modulation for enhanced drug delivery into the brain.
    • File Description:
      application/pdf
    • Relation:
      https://eprints.qut.edu.au/244794/1/151230849.pdf; Da Silva Chaves, Juliana Cristina, Dando, Samantha, White, Anthony, & Oikari, Lotta (2024) Blood-brain barrier transporters: An overview of function, dysfunction in Alzheimer's disease and strategies for treatment. Biochimica et Biophysica Acta - Molecular Basis of Disease, 1870(2), Article number: 166967.; https://eprints.qut.edu.au/244794/; Centre for Immunology and Infection Control; Faculty of Health; School of Biomedical Sciences
    • الدخول الالكتروني :
      https://eprints.qut.edu.au/244794/
    • Rights:
      free_to_read ; http://creativecommons.org/licenses/by-nc-nd/4.0/ ; 2023 Elsevier B.V. ; This work is covered by copyright. Unless the document is being made available under a Creative Commons Licence, you must assume that re-use is limited to personal use and that permission from the copyright owner must be obtained for all other uses. If the document is available under a Creative Commons License (or other specified license) then refer to the Licence for details of permitted re-use. It is a condition of access that users recognise and abide by the legal requirements associated with these rights. If you believe that this work infringes copyright please provide details by email to qut.copyright@qut.edu.au
    • الرقم المعرف:
      edsbas.F1583B88