Polygenic risk scores and breast and epithelial ovarian cancer risks for carriers of BRCA1 and BRCA2 pathogenic variants.

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Litwin Center for Cancer Genetics, Toronto, ON, Canada. 12University of Toronto, Department of Molecular Genetics, Toronto, ON, Canada. 13University Hospital of Schleswig-Holstein, Campus Kiel, Christian-Albrechts University Kiel, Department of Gynaecology and Obstetrics, Kiel, Germany. 14University Hospital of Schleswig-Holstein, Campus Kiel, Christian-Albrechts University Kiel, Institute of Clinical Molecular Biology, Kiel, Germany. 15University of Texas MD Anderson Cancer Center, Department of Breast Medical Oncology, Houston, TX, USA. 16Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Unit of Medical Genetics, Department of Medical Oncology and Hematology, Milan, Italy. 17Vall d'Hebron Institute of Oncology, High Risk and Cancer Prevention Group, Barcelona, Spain. 18University Hospital of Vall d'Hebron, Department of Medical Oncology, Barcelona, Spain. 19Landspitali University Hospital, Department of Pathology, Reykjavik, Iceland. 20University of Iceland, BMC (Biomedical Centre), Faculty of Medicine, Reykjavik, Iceland. 21Centro de Investigación en Red de Enfermedades Raras (CIBERER), Madrid, Spain. 22Spanish National Cancer Research Centre (CNIO), Human Cancer Genetics Programme, Madrid, Spain. 23Centre François Baclesse, Département de Biopathologie, Caen, France. 24Pomeranian Medical University, Department of Genetics and Pathology, Szczecin, Poland. 25University of California San Francisco, Cancer Genetics and Prevention Program, San Francisco, CA, USA. 26Maastricht University Medical Center, Department of Clinical Genetics, Maastricht, The Netherlands. 27IEO, European Institute of Oncology IRCCS, Division of Cancer Prevention and Genetics, Milan, Italy. 28Zealand University Hospital, Clinical Genetic Unit, Department of Paediatrics, Roskilde, Denmark. 29Lund University, Division of Oncology and Pathology, Department of Clinical Sciences Lund, Lund, Sweden. 30National Institute of Oncology, Department of Molecular Genetics, Budapest, Hungary. 31Perelman School of Medicine at the University of Pennsylvania, Department of Medicine, Abramson Cancer Center, Philadelphia, PA, USA. 32Institute of Genetic Medicine, International Centre for Life, Northern Genetic Service, Newcastle upon Tyne, UK. 33Royal Devon & Exeter Hospital, Department of Clinical Genetics, Exeter, UK. 34ONCOBELL-IDIBELL-IDIBGI-IGTP, Catalan Institute of Oncology, CIBERONC, Hereditary Cancer Program, Barcelona, Spain. 35Huntsman Cancer Institute, Department of Medicine, Salt Lake City, UT, USA. 36CIBERONC, Hospital Clinico San Carlos, IdISSC (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos), Molecular Oncology Laboratory, Madrid, Spain. 37University Hospital, SOD Genetica Molecolare, Pisa, Italy. 38Peter MacCallum Cancer Center, Melbourne, VIC, Australia. 39The University of Melbourne, Sir Peter MacCallum Department of Oncology, Melbourne, VIC, Australia. 40Aarhus University Hospital, Department of Clinical Medicine,, Aarhus, Denmark. 41Columbia University, Departments of Pediatrics and Medicine, New York, NY, USA. 42Ghent University, Centre for Medical Genetics, Ghent, Belgium. 43Institut Curie, Service de Génétique, Paris, France. 44CHU de Besançon, Service de Génétique, Besançon, France. 45Sheffield Children's Hospital, Sheffield Clinical Genetics Service, Sheffield, UK. 46Fox Chase Cancer Center, Department of Clinical Genetics, Philadelphia, PA, USA. 47Queen Elizabeth University Hospitals, Department of Clinical Genetics, Glasgow, UK. 48CHU Nantes, Laboratoire de genetique moleculaire, Nantes, France. 49Leiden University Medical Center, Department of Pathology, Leiden, The Netherlands. 50Leiden University Medical Center, Department of Human Genetics, Leiden, The Netherlands. 51Vall dHebron Institute of Oncology (VHIO), Oncogenetics Group, Barcelona, Spain. 52University Hospital Vall dHebron, Clinical and Molecular Genetics Area, Barcelona, Spain. 53Beckman Research Institute of City of Hope, Department of Population Sciences, Duarte, CA, USA. 54University of Pennsylvania, Basser Center for BRCA, Abramson Cancer Center, Philadelphia, PA, USA. 55University of Pretoria, Department of Genetics, Arcadia, South Africa. 56Centre Hospitalier Universitaire de Québec - 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Petrov Institute of Oncology, St. Petersburg, Russia. 91Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC, USA. 92Guy's and St Thomas' NHS Foundation Trust, Clinical Genetics, London, UK. 93Pomeranian Medical University, Independent Laboratory of Molecular Biology and Genetic Diagnostics, Szczecin, Poland. 94Peter MacCallum Cancer Center, Parkville Familial Cancer Centre, Melbourne, VIC, Australia. 95Vilnius University Hospital Santariskiu Clinics, Hematology, Oncology and Transfusion Medicine Center, Department of Molecular and Regenerative Medicine, Vilnius, Lithuania. 96State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania. 97Stanford Cancer Institute, Stanford University School of Medicine, Department of Medicine, Division of Oncology, Stanford, CA, USA. 98Memorial Sloan-Kettering Cancer Center, Clinical Genetics Research Lab, Department of Cancer Biology and Genetics, New York, NY, USA. 99University of California at Los Angeles, David Geffen School of Medicine, Department of Obstetrics and Gynecology, Los Angeles, CA, USA. 100Cedars-Sinai Medical Center, Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Los Angeles, CA, USA. 101Department of Gynecology and Obstetrics, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany. 102University Medical Center Utrecht, Department of Medical Genetics, Utrecht, The Netherlands. 103Odense University Hospital, Department of Clinical Genetics, Odense, Denmark. 104Cancer Genetics Centre, Hong Kong Hereditary Breast Cancer Family Registry, Happy Valley, Hong Kong. 105The University of Hong Kong, Department of Surgery, Pok Fu Lam, Hong Kong. 106Hong Kong Sanatorium and Hospital, Department of Surgery, Happy Valley, Hong Kong. 107Centre Léon Bérard, Unité de Prévention et d'Epidémiologie Génétique, Lyon, France. 108Lyon University, UMR CNRS 5558, Lyon, France. 109Karolinska Institutet, Department of Oncology, Stockholm, Sweden. 110Magee-Womens Hospital, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. 111Centre Antoine Lacassagne, Département d'Hématologie-Oncologie Médicale, Nice, France. 112Amsterdam UMC, location AMC, Department of Clinical Genetics, Amsterdam, The Netherlands. 113University of Munich, Campus Großhadern, Department of Gynecology and Obstetrics, Munich, Germany. 114Radboud University Medical Center, Department of Human Genetics, Nijmegen, The Netherlands. 115Roswell Park Cancer Institute, NRG Oncology, Statistics and Data Management Center, Buffalo, NY, USA. 116Veneto Institute of Oncology IOV - IRCCS, Immunology and Molecular Oncology Unit, Padua, Italy. 117Memorial Sloan-Kettering Cancer Center, Clinical Genetics Service, Department of Medicine, New York, NY, USA. 118University of Toronto, Department of Laboratory Medicine and Pathobiology, Toronto, ON, Canada. 119University Health Network, Laboratory Medicine Program, Toronto, ON, Canada. 120University of Helsinki, Department of Obstetrics and Gynecology, Helsinki University Hospital, Helsinki, Finland. 121University Hospital Düsseldorf, Heinrich-Heine University Düsseldorf, Department of Gynecology and Obstetrics, Düsseldorf, Germany. 122Rigshospitalet, Copenhagen University Hospital, Center for Genomic Medicine, Copenhagen, Denmark. 123Latvian Biomedical Research and Study Centre, Riga, Latvia. 124Oncogénétique Clinique and Aix Marseille Univ, INSERM, IRD, SESSTIM, Institut Paoli-Calmettes, Département d'Anticipation et de Suivi des Cancers, Marseille, France. 125The University of Chicago, Center for Clinical Cancer Genetics, Chicago, IL, USA. 126Birmingham Women's Hospital Healthcare NHS Trust, West Midlands Regional Genetics Service, Birmingham, UK. 127Cambridge University Hospitals NHS Foundation Trust, East Anglian Medical Genetics Service, Cambridge, UK. 128Campus Virchov Klinikum, Charite, Institute of Human Genetics, Berlin, Germany. 129University of Florence, Department of Experimental and Clinical Biomedical Sciences 'Mario Serio', Medical Genetics Unit, Florence, Italy. 130Seoul National University College of Medicine, Department of Preventive Medicine, Seoul, Korea. 131Seoul National University Graduate School, Department of Biomedical Sciences, Seoul, Korea. 132Seoul National University, Cancer Research Institute, Seoul, Korea. 133QIMR Berghofer Medical Research Institute, Department of Genetics and Computational Biology, Brisbane, QLD, Australia. 134Aalborg University Hospital, Molecular Diagnostics, Aalborg, Denmark. 135Aalborg University Hospital, Clinical Cancer Research Center, Aalborg, Denmark. 136Aalborg University, Department of Clinical Medicine, Aalborg, Denmark. 137Portuguese Oncology Institute, Department of Genetics, Porto, Portugal. 138IFOM - the FIRC Institute of Molecular Oncology, Genome Diagnostics Program, Milan, Italy. 139Medical University of Vienna, Dept of OB/GYN and Comprehensive Cancer Center, Vienna, Austria. 140The University of Melbourne, Department of Medicine, St Vincent's Hospital, Fitzroy, VIC, Australia. 141The University of Melbourne, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, Melbourne, VIC, Australia. 142IDIBELL (Bellvitge Biomedical Research Institute), Catalan Institute of Oncology, ProCURE, Barcelona, Spain. 143Fondazione IRCCS Istituto Nazionale dei Tumori (INT), Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Research, Milan, Italy. 144Klinikum rechts der Isar der Technischen Universität München, Department of Gynaecology and Obstetrics, Munich, Germany. 145University of NSW Sydney, School of Women's and Children's Health, Faculty of Medicine, Sydney, NSW, Australia. 146The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Sydney, NSW, Australia. 147University of NSW Sydney, Adult Cancer Program, Lowy Cancer Research Centre, Sydney, NSW, Australia. 148Karolinska Institutet, Clinical Genetics, Stockholm, Sweden. 149Carmel Medical Center and Technion Faculty of Medicine, Clalit National Cancer Control Center, Haifa, Israel. 150Yale School of Medicine, Chronic Disease Epidemiology, New Haven, CT, USA. 151Region of Southern Denmark, Vejle Hospital, Department of Clinical Genetics, Vejle, Denmark. 152Wexner Medical Center, The Ohio State University, Department of Gynecology and Obstetrics, Columbus, OH, USA. 153Unité d'Oncogénétique Centre de Lutte contre le Cancer Paul Strauss, Strasbourg, France. 154Institut de Cancérologie Strasbourg Europe, ICANS, Strasbourg, France. 155Université de Strasbourg, Laboratoire d'ImmunoRhumatologie Moléculaire, Plateforme GENOMAX, INSERM UMR_S 1109, LabEx TRANSPLANTEX, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Faculté de Médecine, Strasbourg, France. 156The Ohio State University, Clinical Cancer Genetics Program, Division of Human Genetics, Department of Internal Medicine, The Comprehensive Cancer Center, Columbus, OH, USA. 157University of Kansas Medical Center, Department of Internal Medicine, Division of Medical Oncology, Westwood, KS, USA. 158Princess Anne Hospital, Southampton, UK. 159City of Hope, Clinical Cancer Genomics, Duarte, CA, USA. 160Monash University, Precision Medicine, School of Clinical Sciences at Monash Health, Clayton, VIC, Australia. 161The University of Melbourne, Department of Clinical Pathology, Melbourne, VIC, Australia. 162Cancer Council Victoria, Cancer Epidemiology Division, Melbourne, VIC, Australia. 163Hannover Medical School, Institute of Human Genetics, Hannover, Germany. 164INSERM U830, Department of Tumour Biology, Paris, France. 165Université Paris Descartes, Paris, France. 166University Hospital Heidelberg, Institute of Human Genetics, Heidelberg, Germany. 167University of Porto, Biomedical Sciences Institute (ICBAS), Porto, Portugal. 168Cancer Research Malaysia, Breast Cancer Research Programme, Subang Jaya, Selangor, Malaysia. 169University of Malaya, Department of Surgery, Faculty of Medicine, Kuala Lumpur, Malaysia. 170Magee-Womens Hospital, University of Pittsburgh School of Medicine, Department of Medicine, Pittsburgh, PA, USA. 171McGill University, Program in Cancer Genetics, Departments of Human Genetics and Oncology, Montréal, QC, Canada. 172University of Cambridge, Department of Medical Genetics, National Institute for Health Research Cambridge Biomedical Research Centre, Cambridge, UK. 173The Ohio State University, Department of Cancer Biology and Genetics, Columbus, OH, USA. 174University Of Melbourne, Department of Medicine, Melbourne, VIC, Australia. 175Beth Israel Deaconess Medical Center, Department of Medical Oncology, Boston, MA, USA. 176Amsterdam UMC, location VUmc, Department of Clinical Genetics, Amsterdam, The Netherlands. 177Fundación Pública Galega de Medicina Xenómica, Santiago de Compostela, Spain. 178Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago, SERGAS, Santiago de Compostela, Spain. 179Oxford University Hospitals, Oxford Centre for Genomic Medicine, Oxford, UK. 180University Hospital Ulm, Department of Gynaecology and Obstetrics, Ulm, Germany. 181Mayo Clinic, Department of Oncology, Rochester, MN, USA. 182Faculty of Medicine and University Hospital Cologne, University of Cologne, Center for Molecular Medicine Cologne (CMMC), Cologne, Germany. 183Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.

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2020

Hirsla - Landspítali University Hospital research archive

1530-0366

https://www.nature.com/articles/s41436-020-0862-x; Barnes DR, Rookus MA, McGuffog L, et al. Polygenic risk scores and breast and epithelial ovarian cancer risks for carriers of BRCA1 and BRCA2 pathogenic variants [published online ahead of print, 2020 Jul 15]. Genet Med. 2020;10.1038/s41436-020-0862-x. doi:10.1038/s41436-020-0862-x; http://hdl.handle.net/2336/621505; Genetics in medicine : official journal of the American College of Medical Genetics

10.1038/s41436-020-0862-x

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