Item request has been placed! ×
Item request cannot be made. ×
loading  Processing Request

HIV-1 Vif: a guardian of the virus that opens up a new era in the research field of restriction factors.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • Contributors:
      高折, 晃史; 10602344
    • بيانات النشر:
      Frontiers
    • الموضوع:
      2013
    • Collection:
      Kyoto University Research Information Repository (KURENAI) / 京都大学学術情報リポジトリ
    • نبذة مختصرة :
      The research on virion infectivity factor (Vif) protein had started in late 1980s right after HIV-1 was cloned, and the function of Vif had been a mystery for a long time. However, the research on Vif has finally lead to the identification of APOBEC3G, which opens up a new era in the research field of host restriction factors in HIV-1 infection followed by TRIM5α, Tetherin/BST-2, and SAMHD1. This suggests that continuation of basic research on fundamental questions is quite important. We still have many questions on Vif and APOBEC3 and should continue to work on these proteins in the future in order to better regulate HIV-1. We will discuss not only the history but also recent advances in Vif research.
    • File Description:
      application/pdf
    • ISSN:
      1664-302X
    • Relation:
      http://hdl.handle.net/2433/173770; Frontiers in microbiology; 34
    • Rights:
      © 2013 Takaori-Kondo and Shindo. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
    • الرقم المعرف:
      edsbas.EA07AEA7