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Study protocol: short against long antibiotic therapy for infected orthopedic sites - the randomized-controlled SALATIO trials
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- المؤلفون: Uçkay, Ilker; Wirth, Stephan; Zörner, Björn; Fucentese, Sandro; Wieser, Karl; Schweizer, Andreas; Müller, Daniel; Zingg, Patrick; Farshad, Mazda
- المصدر:
Uçkay, Ilker; Wirth, Stephan; Zörner, Björn; Fucentese, Sandro; Wieser, Karl; Schweizer, Andreas; Müller, Daniel; Zingg, Patrick; Farshad, Mazda (2023). Study protocol: short against long antibiotic therapy for infected orthopedic sites - the randomized-controlled SALATIO trials. Trials, 24:117.
- الموضوع:
- نوع التسجيلة:
article in journal/newspaper
- اللغة:
English
- معلومة اضافية
- بيانات النشر:
BioMed Central
- الموضوع:
2023
- Collection:
University of Zurich (UZH): ZORA (Zurich Open Repository and Archive
- نبذة مختصرة :
BACKGROUND: Few studies address the appropriate duration of post-surgical antibiotic therapy for orthopedic infections; with or without infected residual implants. We perform two similar randomized-clinical trials (RCT) to reduce the antibiotic use and associated adverse events. METHODS: Two unblinded RCTs in adult patients (non-inferiority with a margin of 10%, a power of 80%) with the primary outcomes "remission" and "microbiologically-identical recurrences" after a combined surgical and antibiotic therapy. The main secondary outcome is antibiotic-related adverse events. The RCTs allocate the participants between 3 vs. 6 weeks of post-surgical systemic antibiotic therapy for implant-free infections and between 6 vs. 12 weeks for residual implant-related infections. We need a total of 280 episodes (randomization schemes 1:1) with a minimal follow-up of 12 months. We perform two interim analyses starting approximately after 1 and 2 years. The study approximatively lasts 3 years. DISCUSSION: Both parallel RCTs will enable to prescribe less antibiotics for future orthopedic infections in adult patients.
- File Description:
application/pdf
- ISSN:
1745-6215
- Relation:
https://www.zora.uzh.ch/id/eprint/232801/1/Study_protocol.pdf; info:pmid/36803837; urn:issn:1745-6215
- الرقم المعرف:
10.5167/uzh-232801
- الرقم المعرف:
10.1186/s13063-023-07141-2
- Rights:
info:eu-repo/semantics/openAccess ; Creative Commons: Attribution 4.0 International (CC BY 4.0) ; http://creativecommons.org/licenses/by/4.0/
- الرقم المعرف:
edsbas.E8F015CF
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