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Possibilities to assess insulin resistance as the metabolic syndrome is clustered in women in postmenopause ; Возможности оценки инсулинорезистентности по мере кластеризации метаболического синдрома у женщин в постменопаузе

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اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • بيانات النشر:
      REMEDIUM GROUP Ltd.
    • الموضوع:
      2019
    • Collection:
      Medical Council (E-Journal) / Медицинский Совет
    • نبذة مختصرة :
      The formation of the MS cluster starting from insulin resistance (IR), visceral obesity, dyslipidemia, arterial hypertension and carbohydrate metabolism disorders (CMD) against the background of estrogenic deficiency defines postmenopause as a risk factor for type 2 diabetes mellitus (DM2) and increased cardiovascular risk. The TyG index (logarithmic ratio of triglyceride and fasting plasma glucose levels) is proposed for surrogate evaluation of IR, reflecting an integrated approach to metabolic disorders.Aim: To assess the relationship between the TyG Index and HOMA2-IR and its informativeness in predicting the risk of DM2 in women in postmenopause.Materials and methods: TyG and HOMA2-IR indices (C-peptide) were determined in 94 postmenopausal women 58.02 ± 5.88 years of age, evaluated according to NCEP ATP III criteria and divided into groups: 1st - DM2, 2nd - prediabetes, 3rd - without CMD (HbAlc 7.3 ± 1.0; 6.2 ± 0.2 and 5.5 ± 0.4%, respectively). By means of SPSS (version 17) we evaluated ME (25-75%); intergroup differences by Mann-Whitney criteria; we performed correlation and ROC-analysis.Results: TyG correlates with HOMA2IR in group 2 (R = 0.61; p = 0.013) and 3 (R = 0.60; p = 0.001). In the process of ROC-analysis cut-off for TyG was revealed, reflecting the chance of presence of DM2 in groups 2 and 3: 7.5 (sensitivity 0.938 and specificity 0.813) and 8.0 (sensitivity 0.894 and specificity 0.810), respectively.Conclusion: TyG index allows predicting the development of dysglycemia in women in postmenopause with the signs of MS through the phenomenon of lipoglucotoxicity. ; Формирование кластера МС, стартующего от инсулинорезистентности (ИР), висцерального ожирения, дислипидемии, артериальной гипертензии и нарушений углеводного обмена (НУО), на фоне эстрогенного дефицита определяет постменопаузу в качестве фактора риска сахарного диабета 2-го типа (СД2) и повышения сердечно-сосудистого риска. Для суррогатной оценки ИР предложен индекс TyG (логарифмическое соотношение уровней триглицеридов и глюкозы плазмы ...
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    • Relation:
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    • الرقم المعرف:
      10.21518/2079-701X-2019-4-88-93
    • الدخول الالكتروني :
      https://www.med-sovet.pro/jour/article/view/3121
      https://doi.org/10.21518/2079-701X-2019-4-88-93
    • Rights:
      Authors publishing their articles in this journal shall agree to the following:Authors reserve the copyright to the work and grant the journal a license to publish the work for the first time Creative Commons Attribution License (CC BY- NC-ND), which allows other persons to distribute this work with the obligatory preservation of references to the authors of the original work and the original publication in this journal.Authors reserve the right to conclude separate contractual arrangements regarding the non-exclusive distribution of the work version in the form published here (for example, posting it in the institute’s repository, publication in a book), with reference to its original publication in this journal.Authors have the right to post work on the Internet (for example, in the institute’s repository or personal website) before and during the process of considering it by this journal, as this can result in a productive discussion and more references to this work. ; Авторы, публикующие в данном журнале, соглашаются со следующим:Авторы сохраняют за собой авторские права на работу и предоставляют журналу право первой публикации работы на условиях лицензии Creative Commons Attribution License (CC BY- NC-ND), которая позволяет другим распространять данную работу с обязательным сохранением ссылок на авторов оригинальной работы и оригинальную публикацию в журнале.Авторы сохраняют право заключать отдельные контрактные договорённости, касающиеся не-эксклюзивного распространения версии работы в опубликованном виде (например, размещение ее в институтском хранилище, публикацию в книге), со ссылкой на ее оригинальную публикацию.Авторы имеют право размещать работу в сети Интернет (например в институтском хранилище или персональном сайте) до и во время процесса рассмотрения ее данным журналом, так как это может привести к продуктивному обсуждению и большему количеству ссылок на данную работу. (См. The Effect of Open Access).
    • الرقم المعرف:
      edsbas.E7F42362