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Cytotoxic T Cell Response to Influenza Vaccination in Older Adults

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  • معلومة اضافية
    • بيانات النشر:
      ODU Digital Commons
    • الموضوع:
      2000
    • Collection:
      Old Dominion University: ODU Digital Commons
    • نبذة مختصرة :
      Influenza infections result in activation of cellular and humoral immune responses, leading to stimulation of cytotoxic T cells (CTL) and helper T cells with subsequent viral clearance. By using an assay of granzyme B activity, the in vivo cellular-mediated immune response of old adults was found to be significantly decreased in comparison to young adults. The effect of aging on the CTL response was further investigated via enzyme-linked immunospot technique. A significant increase in number of virus-specific T cells occurred in older adults after vaccination, although the magnitude of the CTL response decreased in comparison to young adults. These data suggest that a mechanistic defect in the CTL response caused the decreased response of the CD8+ T cells in older adults; and provides a basis for further investigation of age-related changes in the mechanism of the CTL response to influenza vaccination in older adults.
    • File Description:
      application/pdf
    • Relation:
      https://digitalcommons.odu.edu/chemistry_etds/33; https://digitalcommons.odu.edu/context/chemistry_etds/article/1044/viewcontent/Letter_1401832.pdf
    • الرقم المعرف:
      10.25777/61vj-bq55
    • Rights:
      In Copyright. URI: http://rightsstatements.org/vocab/InC/1.0/ This Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).
    • الرقم المعرف:
      edsbas.E65DA9D6