Study on the intestinal absorption mechanism of green tea catechins and hawthorn flavonoids using caco-2 cell monolayer model.

Zhang Li. ; Thesis (M.Phil.)--Chinese University of Hong Kong, 2003. ; Includes bibliographical references (leaves 148-159). ; Abstracts in English and Chinese. ; Acknowledgements --- p.I ; Abstract --- p.II ; Abstract (in Chinese) --- p.IV ; Publications --- p.V ; List of Abbreviations --- p.VI ; List of Tables --- p.VII ; List of Figures --- p.VIII ; Table of Contents --- p.XIII ; Chapter Chapter One. --- Introduction --- p.1 ; Chapter 1.1 --- Flavonoids --- p.1 ; Chapter 1.2 --- Tea --- p.4 ; Chapter 1.2.1 --- Composition of green tea catechins (GTC) --- p.4 ; Chapter 1.2.2 --- Pharmacological activity --- p.6 ; Chapter 1.2.2.1 --- Anticarcinogenic activity --- p.6 ; Chapter 1.2.2.2 --- Antioxidative activity --- p.7 ; Chapter 1.2.2.3 --- Radical scavenge --- p.7 ; Chapter 1.2.2.4 --- Cardiovascular activity --- p.8 ; Chapter 1.2.3 --- Pharmacokinetics of GTC --- p.8 ; Chapter 1.2.3.1 --- Absorption --- p.10 ; Chapter 1.2.3.2 --- Distribution --- p.11 ; Chapter 1.2.3.3 --- Elimination --- p.11 ; Chapter 1.2.3.4 --- Metabolism --- p.12 ; Chapter 1.2.3.4.1 --- Metabolism in the small intestine --- p.12 ; Chapter 1.2.3.4.2 --- Metabolism in the liver --- p.13 ; Chapter 1.2.3.5 --- Summary of the pharmacokinetics of GTC --- p.13 ; Chapter 1.3 --- Hawthorn --- p.14 ; Chapter 1.3.1 --- Composition of hawthorn --- p.14 ; Chapter 1.3.2 --- Pharmacological activity --- p.16 ; Chapter 1.3.2.1 --- Inotonic activity --- p.16 ; Chapter 1.3.2.2 --- Antiarrhythmic activity --- p.17 ; Chapter 1.3.2.3 --- Hypolipidemic activity --- p.17 ; Chapter 1.3.2.4 --- Antihypertensive activity --- p.18 ; Chapter 1.3.2.5 --- Antioxidative activity --- p.18 ; Chapter 1.3.3 --- Pharmacokinetics of HF --- p.18 ; Chapter 1.3.3.1 --- Absorption --- p.19 ; Chapter 1.3.3.2 --- Distribution and elimination --- p.21 ; Chapter 1.3.3.3 --- Summary of pharmacokinetic of HF --- p.22 ; Chapter 1.4 --- Mechanisms of intestinal absorption --- p.22 ; Chapter 1.4.1 --- Passive transcellular transport --- p.23 ; Chapter 1.4.2 --- Paracellular transport ...