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High sensitivity of PHHC rat to dietary cholesterol

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  • معلومة اضافية
    • Collection:
      Czech Academy of Sciences: dKNAV / Knihovna Akademie věd České Republiky
    • نبذة مختصرة :
      The Prague Hereditary Hypercholesterolaemic (PHHC) rat is a strain of the Wistar rat very sensitive to dietary cholesterol.The dynamics of changes in serum and liver lipids and lecithin : cholesterol acyltransferase (LCAT) were studied immediatelly after the switch to a high cholesterol diet. Immediate cumulation of free and esterified cholesterol in the liver after the increase in alimentary cholesterol intake is supposed to be the regulating step leading to a subsequent increase in serum cholesterol concentration. Activity of LCAT was negatively correlated to the concentration of free cholesterol in the liver, very early after the cholesterol diet was introduced, a possibility of a down regulation of enzyme synthesis similarly to the regulation of synthesis of cholesterol in hepatocytes was observed.
    • Relation:
      https://kramerius.lib.cas.cz/view/uuid:8d4cd2b0-3771-4dd5-a717-82cdd17c38e4
    • الدخول الالكتروني :
      https://kramerius.lib.cas.cz/view/uuid:8d4cd2b0-3771-4dd5-a717-82cdd17c38e4
    • Rights:
      policy:public
    • الرقم المعرف:
      edsbas.E4EBB731