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Interindividual variability in the cholesterol-lowering effect of supplementation with plant sterols or stanols

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  • معلومة اضافية
    • Contributors:
      Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)); École pratique des hautes études (EPHE); Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU); Mer, molécules et santé EA 2160 (MMS); Université de Nantes - UFR des Sciences Pharmaceutiques et Biologiques; Université de Nantes (UN)-Université de Nantes (UN)-Le Mans Université (UM)-Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST); Université de Nantes (UN)-Université de Nantes (UN); FR 3473 Institut universitaire Mer et Littoral (IUML); Le Mans Université (UM)-Université d'Angers (UA)-Université de Nantes (UN)-École Centrale de Nantes (ECN)-Université de Bretagne Sud (UBS)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Centre National de la Recherche Scientifique (CNRS); Centre de Recherche en Nutrition Humaine (CRNH); Centre hospitalier universitaire de Nantes (CHU Nantes); Institut de Cancérologie de l'Ouest Angers/Nantes (UNICANCER/ICO); UNICANCER; Institut Pasteur de Lille; Réseau International des Instituts Pasteur (RIIP)
    • بيانات النشر:
      HAL CCSD
      Oxford University Press (OUP)
    • الموضوع:
      2017
    • Collection:
      Archive ouverte HAL (Hyper Article en Ligne, CCSD - Centre pour la Communication Scientifique Directe)
    • نبذة مختصرة :
      International audience ; Low-density lipoprotein cholesterol (LDL-C) plays a causal role in atherosclerosis. One way to reduce LDL-C levels is to inhibit cholesterol absorption. Plant sterols and stanols compete with cholesterol for absorption in the intestine and induce an average decrease in LDL-C by 5% to 15% in a dose-dependent manner, but not in all individuals. This review focuses on the interindividual variability in response to dietary supplementation with plant sterols and stanols. Dietary plant sterols and stanols have no significant effects on LDL-C in substantial numbers of individuals. Higher responses, in absolute value and percentage of LDL-C, are observed in individuals with higher cholesterol absorption and a lower rate of cholesterol synthesis. Some data provide evidence of the influence of genetics on the response to plant sterols and stanols. Further studies in large populations are required to extend these conclusions about genetic influences.
    • Relation:
      info:eu-repo/semantics/altIdentifier/pmid/28158760; inserm-02452775; https://www.hal.inserm.fr/inserm-02452775; https://www.hal.inserm.fr/inserm-02452775/document; https://www.hal.inserm.fr/inserm-02452775/file/physio_indiv_response_r7.pdf; PUBMED: 28158760
    • الرقم المعرف:
      10.1093/nutrit/nuw059
    • الدخول الالكتروني :
      https://www.hal.inserm.fr/inserm-02452775
      https://www.hal.inserm.fr/inserm-02452775/document
      https://www.hal.inserm.fr/inserm-02452775/file/physio_indiv_response_r7.pdf
      https://doi.org/10.1093/nutrit/nuw059
    • Rights:
      info:eu-repo/semantics/OpenAccess
    • الرقم المعرف:
      edsbas.E471297E