نبذة مختصرة : Vaginally cancer is a rare malignancy that happens in the cells of the vagina and pharmacological interventions play a major role managing vaginal cancer. Cisplatin, a platinum _ based chemotherapy drug, is used in a wide manner regarding the treatment of different types of cancers along with vaginal cancer. Cisplatin performs by interfering with the DNA inside the cancer cells, stopping their capability to divide and grow. 5_ Fluorosis uracil (5_ Fu) is an anti-metabolite drug that disrupts the synthesis of DNA and RNA, stopping the growth of cancer cells. Trastuzumide (Herceptin) is a mono clonal antibody that targets the HER 2 protein, which is over expressed in a very few types of vaginally cancers. By inhibiting HER2, trastuzumab stopsvthe growth if cancer cells. Bevacizumab is an anti_ angiogenic drug that stops the formation of new blood vessels in tumors. By stopping the blood supply, it limits the tumors ability to grow and spread. Bevacizumab may be used along with chemotherapy especially for advanced cases. Tamoxifen, an estrogen receptor modulator , interfere with the capability of estrogen, thereby slowing down or stopping the growth of hormone _ sensitive tumors. Pembroluzumab has exhibited promise particularly in certain ctypes of vaginal cancer, specifically those with micro satellite instability, high ( MSI _ H) or mismatch repair deficient ( d MMR) status. Finally it is concluded that while surgical or radiation interventions remain corner stone’s regarding management of vaginal cancer.
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