SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids

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المؤلفون: Jansen J.; Reimer K. C.; Nagai J. S.; Varghese F. S.; Overheul G. J.; de Beer M.; Roverts R.; Daviran D.; Fermin L. A. S.; Willemsen B.; Beukenboom M.; Djudjaj S.; von Stillfried S.; van Eijk L. E.; Mastik M.; Bulthuis M.; Dunnen W. D.; van Goor H.; Hillebrands J. -L.; Triana S. H.; Alexandrov T.; Timm M. -C.; van den Berge B. T.; van den Broek M.; Nlandu Q.; Heijnert J.; Bindels E. M. J.; Hoogenboezem R. M.; Mooren F.; Kuppe C.; Miesen P.; Grunberg K.; Ijzermans T.; Steenbergen E. J.; Czogalla J.; Schreuder M. F.; Sommerdijk N.; Akiva A.; Boor P.; Puelles V. G.; Floege J.; Huber T. B.; Achdout H.; Aimon A.; Bar-David E.; Barr H.; Ben-Shmuel A.; Bennett J.; Boby M. L.; Borden B.; Bowman G. R.; Brun J.; BVNBS S.; Calmiano M.; Carbery A.; Cattermole E.; Chernychenko E.; Choder J. D.; Clyde A.; Coffland J. E.; Cohen G.; Cole J.; Contini A.; Cox L.; Cvitkovic M.; Dias A.; Donckers K.; Dotson D. L.; Douangamath A.; Duberstein S.; Dudgeon T.; Dunnett L.; Eastman P. K.; Erez N.; Eyermann C. J.; Fairhead M.; Fate G.; Fearon D.; Federov O.; Ferla M.; Fernandes R. S.; Ferrins L.; Foster R.; Foster H.; Gabizon R.; Garcia-Sastre A.; Gawriljuk V. O.; Gehrtz P.; Gileadi C.; Giroud C.; Glass W. G.; Glen R.; Itai glinert; Godoy A. S.; Gorichko M.; Gorrie-Stone T.; Griffen E. J.; Hart S. H.; Heer J.; Henry M.; Hill M.; Horrell S.; Hurley M. F. D.; Israely T.; Jajack A.; Jnoff E.; Jochmans D.; John T.; De Jonghe S.; Kantsadi A. L.; Kenny P. W.; Kiappes J. L.; Koekemoer L.; Kovar B.; Krojer T.; Lee A. A.; Lefker B. A.; Levy H.; London N.; Lukacik P.; Macdonald H. B.; Maclean B.; Malla T. R.; Matviiuk T.; McCorkindale W.; McGovern B. L.; Melamed S.; Michurin O.; Mikolajek H.; Milne B. F.; Morris A.; Morris G. M.; Morwitzer M. J.; Moustakas D.; Nakamura A. M.; Neto J. B.; Neyts J.; Nguyen L.; Noske G. D.; Oleinikovas V.; Oliva G.; Owen D.; Psenak V.; Pai R.; Pan J.; Paran N.; Perry B.; Pingle M.; Pinjari J.; Politi B.; Powell A.; Puni R.; Rangel V. L.; Reddi R. N.; Reid S. P.; Resnick E.; Ripka E. G.; Robinson M. C.; Robinson R. P.; Rodriguez-Guerra J.; Rosales R.; Rufa D.; Schofield C.; Shafeev M.; Shaikh A.; Shi J.; Shurrush K.; Sing S.; Sittner A.; Skyner R.; Smalley A.; Smilova M. D.; Solmesky L. J.; Spencer J.; Strain-Damarell C.; Swamy V.; Tamir H.; Tennant R.; Thompson W.; Thompson A.; Tomasia S.; Tumber A.; Vakonakis I.; van Rij R. P.; van Geel L.; Vaschetto M.; Vitner E. B.; Voelz V.; Volkamer A.; von Delft F.; von Delft A.; Walsh M.; Ward W.; Weatherall C.; Weiss S.; White K. M.; Wild C. F.; Wittmann M.; Wright N.; Yahalom-Ronen Y.; Zaidmann D.; Zidane H.; Zitzmann N.; Costa I. G.; Schneider R. K.; Smeets B.; Kramann R.
الموضوع:
chronic kidney disease; COVID-19; fibrosi; human iPSC kidney organoid; kidney injury; protease blocker; SARS-CoV-2; Human; Kidney; Organoid; Settore CHIM/06 - Chimica Organica; Settore MED/04 - Patologia Generale
نوع التسجيلة:
article in journal/newspaper
اللغة:
English

معلومة اضافية
- Contributors:
  J. Jansen; K.C. Reimer; J.S. Nagai; F.S. Varghese; G.J. Overheul; M. de Beer; R. Rovert; D. Daviran; L.A.S. Fermin; B. Willemsen; M. Beukenboom; S. Djudjaj; S. von Stillfried; L.E. van Eijk; M. Mastik; M. Bulthui; W.D. Dunnen; H. van Goor; J.-. Hillebrand; S.H. Triana; T. Alexandrov; M.-. Timm; B.T. van den Berge; M. van den Broek; Q. Nlandu; J. Heijnert; E.M.J. Bindel; R.M. Hoogenboezem; F. Mooren; C. Kuppe; P. Miesen; K. Grunberg; T. Ijzerman; E.J. Steenbergen; J. Czogalla; M.F. Schreuder; N. Sommerdijk; A. Akiva; P. Boor; V.G. Puelle; J. Floege; T.B. Huber; H. Achdout; A. Aimon; E. Bar-David; H. Barr; A. Ben-Shmuel; J. Bennett; M.L. Boby; B. Borden; G.R. Bowman; J. Brun; S. Bvnb; M. Calmiano; A. Carbery; E. Cattermole; E. Chernychenko; J.D. Choder; A. Clyde; J.E. Coffland; G. Cohen; J. Cole; A. Contini; L. Cox; M. Cvitkovic; A. Dia; K. Doncker; D.L. Dotson; A. Douangamath; S. Duberstein; T. Dudgeon; L. Dunnett; P.K. Eastman; N. Erez; C.J. Eyermann; M. Fairhead; G. Fate; D. Fearon; O. Federov; M. Ferla; R.S. Fernande; L. Ferrin; R. Foster; H. Foster; R. Gabizon; A. Garcia-Sastre; V.O. Gawriljuk; P. Gehrtz; C. Gileadi; C. Giroud; W.G. Gla; R. Glen; G. Itai; A.S. Godoy; M. Gorichko; T. Gorrie-Stone; E.J. Griffen; S.H. Hart; J. Heer; M. Henry
- بيانات النشر:
  Cell Press
- الموضوع:
  2022
- Collection:
  The University of Milan: Archivio Istituzionale della Ricerca (AIR)
- نبذة مختصرة :
  Kidney failure is frequently observed during and after COVID-19, but it remains elusive whether this is a direct effect of the virus. Here, we report that SARS-CoV-2 directly infects kidney cells and is associated with increased tubule-interstitial kidney fibrosis in patient autopsy samples. To study direct effects of the virus on the kidney independent of systemic effects of COVID-19, we infected human-induced pluripotent stem-cell-derived kidney organoids with SARS-CoV-2. Single-cell RNA sequencing indicated injury and dedifferentiation of infected cells with activation of profibrotic signaling pathways. Importantly, SARS-CoV-2 infection also led to increased collagen 1 protein expression in organoids. A SARS-CoV-2 protease inhibitor was able to ameliorate the infection of kidney cells by SARS-CoV-2. Our results suggest that SARS-CoV-2 can directly infect kidney cells and induce cell injury with subsequent fibrosis. These data could explain both acute kidney injury in COVID-19 patients and the development of chronic kidney disease in long COVID.
- Relation:
  info:eu-repo/semantics/altIdentifier/pmid/35032430; info:eu-repo/semantics/altIdentifier/wos/WOS:000753471000008; volume:29; issue:2; firstpage:217; lastpage:231.e8; numberofpages:15; journal:CELL STEM CELL; http://hdl.handle.net/2434/923989; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85123016842
- الرقم المعرف:
  10.1016/j.stem.2021.12.010
- Rights:
  info:eu-repo/semantics/openAccess
- الرقم المعرف:
  edsbas.E41C0119

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SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids

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