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A mini-review of the evidence for cerebrovascular changes following gender-affirming hormone replacement therapy and a call for increased focus on cerebrovascular transgender health

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  • معلومة اضافية
    • بيانات النشر:
      Frontiers Media
    • الموضوع:
      2023
    • Collection:
      Cardiff University: ORCA (Online Research @ Cardiff)
    • نبذة مختصرة :
      Gender-affirming hormone replacement therapy (gaHRT) is an important step for many in the gender diverse community, associated with increased quality-of-life and lower self-reported scores of depression and anxiety. However, considering the interactions that the involved sex hormones have on vasculature (with oestrogen and testosterone demonstrating vasodilatory and vasoconstricting properties, respectively), it is important for transgender healthcare research to examine how the manipulation of these hormones interact with cerebrovascular structure and functioning. There is a stark lack of research in this area. This mini-review outlines the research suggesting a vascular impact of these sex hormones using evidence from a range of cohorts (e.g., menopause, polycystic ovary syndrome) and discusses the work that has been done into cerebrovascular changes following gaHRT. Finally, recommendations for future research into cerebrovascular health in transgender cohorts following gaHRT are outlined.
    • File Description:
      application/pdf
    • Relation:
      https://orca.cardiff.ac.uk/id/eprint/164287/1/fnhum-17-1303871.pdf; Wright, Melissa Emily https://orca.cardiff.ac.uk/view/cardiffauthors/A2133216F.html orcid:0000-0002-2744-4504 orcid:0000-0002-2744-4504 and Murphy, Kevin https://orca.cardiff.ac.uk/view/cardiffauthors/A132678J.html orcid:0000-0002-6516-313X orcid:0000-0002-6516-313X 2023. A mini-review of the evidence for cerebrovascular changes following gender-affirming hormone replacement therapy and a call for increased focus on cerebrovascular transgender health. Frontiers in Human Neuroscience 17 , 1303871. 10.3389/fnhum.2023.1303871 https://doi.org/10.3389/fnhum.2023.1303871 file https://orca.cardiff.ac.uk/id/eprint/164287/1/fnhum-17-1303871.pdf
    • الرقم المعرف:
      10.3389/fnhum.2023.1303871
    • الدخول الالكتروني :
      https://orca.cardiff.ac.uk/id/eprint/164287/
      https://doi.org/10.3389/fnhum.2023.1303871
      https://orca.cardiff.ac.uk/id/eprint/164287/1/fnhum-17-1303871.pdf
    • Rights:
      cc_by_4_0
    • الرقم المعرف:
      edsbas.E1776718