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Effect of very low-calorie ketogenic diet in combination with omega-3 on inflammation, satiety hormones, body composition, and metabolic markers. A pilot study in class I obese subjects

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  • معلومة اضافية
    • Contributors:
      M. Rondanelli; S. Perna; Z. Ilya; G. Peroni; P. Bazire; I. Sajuox; R. Maugeri; M. Nichetti; C. Gasparri
    • بيانات النشر:
      Springer
    • الموضوع:
      2022
    • Collection:
      The University of Milan: Archivio Istituzionale della Ricerca (AIR)
    • نبذة مختصرة :
      Purpose: This study aims to evaluate the effects of a VLCKD combined with omega-3 supplementation (VLCKD diet only lasted for some weeks, and it was followed by a non-ketogenic LCD for the rest of the study period) on body composition, visceral fat, satiety hormones, inflammatory and metabolic markers. Methods: It has been performed a pilot open label study lasted 90 days, in a cohort of 12 women with class I obesity aged 18 to 65 years. Data on body composition (evaluated by Dual X-Ray Absorptiometry—DXA), visceral fat, satiety hormones, inflammatory and metabolic markers were recorded. Results: This study showed a body weight reduction mean difference over time of −13.7 kg and the waist circumference mean difference decrease of −13.3 cm. Also, the fat mass (FM) decreased—9.1 kg and visceral adipose tissue (VAT)—0.41 kg. No effects on fat-free mass (FFM) have been reported. Improvements were observed in the satiety hormones, with increased ghrelin and decreased leptin, and also in the metabolic profiles. Conclusions: A VLCKD combined with omega-3 supplementation appears to be an effective strategy for promoting an high loss of FM with preservation of FFM in patients with class I obesity.
    • Relation:
      info:eu-repo/semantics/altIdentifier/pmid/34532829; info:eu-repo/semantics/altIdentifier/wos/WOS:000696433900001; volume:75; issue:1; firstpage:129; lastpage:136; numberofpages:8; journal:ENDOCRINE; https://hdl.handle.net/2434/956000; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85115117090
    • الرقم المعرف:
      10.1007/s12020-021-02860-5
    • الدخول الالكتروني :
      https://hdl.handle.net/2434/956000
      https://doi.org/10.1007/s12020-021-02860-5
    • Rights:
      info:eu-repo/semantics/openAccess
    • الرقم المعرف:
      edsbas.DF362418