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Multimodal assessment of language and memory reorganization. A proof of concept in two patients with temporal lobe epilepsy. ; Evaluation multimodale de la réorganisation du langage et de la mémoire. Une preuve de concept chez deux patients avec une épilepsie du lobe temporal.

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اقرأ أكثر حفظ في قائمتي
  • معلومة اضافية
    • Contributors:
      Laboratoire de Psychologie et NeuroCognition (LPNC); Université Savoie Mont Blanc (USMB Université de Savoie Université de Chambéry )-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes 2016-2019 (UGA 2016-2019 ); IRMaGe (IRMaGe); Centre Hospitalier Universitaire CHU Grenoble (CHUGA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes 2016-2019 (UGA 2016-2019 ); GIN Grenoble Institut des Neurosciences (GIN); Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes 2016-2019 (UGA 2016-2019 ); Laboratoire de physiopathologie de l'épilepsie (LNPEE); Centre Hospitalier Universitaire CHU Grenoble (CHUGA); Institut de Neurosciences des Systèmes (INS); Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM); This work was supported by grants from ANR ( ANR-17-CE28-0015) in the framework of the “Sociétés innovantes, intégrantes et adaptatives (DS08) 2017” program; and NeuroCoG IDEX UGA in the framework of the “Investissements d’avenir” program (ANR-15-IDEX-02).; Ce travail a été soutenu par des subventions de recherche obtenues de l'ANR ( ANR-17-CE28-0015) dans le cadre du programme "Sociétés innovantes, intégrantes et adaptatives (DS08) 2017" et NeuroCoG IDEX UGA dans le cadre du programme "Investissements d'avenir "(ANR-15-IDEX-02); OHBM (Organization of the human Brain Mapping); ANR-17-CE28-0015,REORG,Réorganisation Neurocognitive du Langage et de la Mémoire chez les Patients avec Epilépsie Focale Temporale. Etude Intégrative et Multidisciplinaire(2017)
    • بيانات النشر:
      CCSD
    • الموضوع:
      2018
    • الموضوع:
      Singapore
    • نبذة مختصرة :
      International audience ; Temporal lobe epilepsy (TLE) accounts for 70-80% of epilepsy in adults (1). The dysfunction (epileptic zone, EZ) is located in the temporal lobe and induces language and memory reorganization of cerebral networks and various degrees of cognitive efficiency. TLE patients should be explored according to a multimodal integrative perspective, based on multiple data on brain activation, cerebral structure and cognitive performance. We present two patients with left TLE compared to a control group (N=12). Data acquisition. Patients underwent neuropsychological, fMRI and MR-DTI. Control group underwent fMRI and MR-DTI. Neuropsychological scores for patients were compared to normative matched samples associated with each of the tests used. Functional MRI and MR-DTI experiments were performed in a whole-body 3T MR scanner (Philips Achieva). Parameters of diffusion tensor sequence for MR-DTI acquisition were: voxel size: 2 x 2 x 2 mm, 128 x 126 slices of 2 mm thickness and no gap, TE = 67.2 ms, TR = 14000ms, EPI factor = 63, field of view = 256 mm, b value = 1500sec / mm2. During fMRI we applied the NEREC protocol (2) to map lexical production. Parameters for manufacturer-provided gradient-echo/T2* weighted EPI used for fMRI were: voxel size 2.75 x 2.75 x 3.5 mm, field of view 220 x 220 x 131.75 acquired with a 88 x 85 pixels and a reconstruction matrix of 96 x 96; TR=2.5 sec, TE=30 msec and flip angle=77°. Data processing. DICOM raw data for MR-DTI was converted to NIFTI (dcm2niix toolbox) before concatenation and pre-processing with Diffusionist software (2,3) running on Linux and based on FSL (FMRIB Software Library v5.0, Oxford UK (4,5) and FMRIB Diffusion Toolbox (FDT). We measured Fractional Anisotropy (FA) to assess white matter (WM) modifications at (a) intra-hemispheric: inferior longitudinal (ILF), inferior fronto-occipital (IFOF), superior longitudinal SLF, arcuate (Arc), uncinate (Unc), cingulum (Cing), fornix (Fox), and (b) inter-hemispheric level in terms of sub-regions of the corpus ...
    • الرقم المعرف:
      10.13140/RG.2.2.20097.35686
    • الدخول الالكتروني :
      https://hal.science/hal-01916827
      https://hal.science/hal-01916827v1/document
      https://hal.science/hal-01916827v1/file/PosterOHBM2018_final.pdf
      https://doi.org/10.13140/RG.2.2.20097.35686
    • Rights:
      info:eu-repo/semantics/OpenAccess
    • الرقم المعرف:
      edsbas.DEF603EC