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Epidemiology of intra-abdominal infection and sepsis in critically ill patients: “AbSeS”, a multinational observational cohort study and ESICM Trials Group Project

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  • معلومة اضافية
    • Contributors:
      Blot, S.; Antonelli, M.; Arvaniti, K.; Blot, K.; Creagh-Brown, B.; de Lange, D.; De Waele, J.; Deschepper, M.; Dikmen, Y.; Dimopoulos, G.; Eckmann, C.; Francois, G.; Girardis, M.; Koulenti, D.; Labeau, S.; Lipman, J.; Lipovestky, F.; Maseda, E.; Montravers, P.; Mikstacki, A.; Paiva, J. -A.; Pereyra, C.; Rello, J.; Timsit, J. -F.; Vogelaers, D.; Lamrous, A.; Rezende-Neto, J.; Cardenas, Y.; Vymazal, T.; Fjeldsoee-Nielsen, H.; Kott, M.; Kostoula, A.; Javeri, Y.; Einav, S.; Makikado, L. D. U.; Tomescu, D.; Gritsan, A.; Jovanovic, B.; Venkatesan, K.; Mirkovic, T.; Emmerich, M.; Canale, M.; Dietz, L. S.; Ilutovich, S.; Minope, J. T. S.; Silva, R. B.; Montenegro, M. A.; Martin, P.; Saul, P.; Chediack, V.; Sutton, G.; Couce, R.; Balasini, C.; Gonzalez, S.; Lascar, F. M.; Descotte, E. J.; Gumiela, N. S.; Pino, C. A.; Cesio, C.; Valgolio, E.; Cunto, E.; Dominguez, C.; Nelson, N. F.; Abegao, E. M.; Pozo, N. C.; Bianchi, L.; Correger, E.; Pastorino, M. L.; Miyazaki, E. A.; Grubissich, N.; Garcia, M.; Bonetto, N.; Quevedo, N. E.; Gomez, C. D.; Queti, F.; Estevarena, L. G.; Fernandez, R.; Santolaya, I.; Grangeat, S. H.; Doglia, J.; Zakalik, G.; Pellegrini, C.; Lloria, M. M.; Chacon, M. E.; Fumale, M.; Leguizamon, M.; Hidalgo, I. B.; Tiranti, R. J.; Capponi, P.; Tita, A.; Cardonnet, L.; Bettini, L.; Ramos, A.; Lovesio, L.; Miranda, E. M.; Farfan, A. B.
    • الموضوع:
      2019
    • Collection:
      Università degli Studi di Foggia: CINECA IRIS Institutional Research Information System
    • نبذة مختصرة :
      Purpose: To describe the epidemiology of intra-abdominal infection in an international cohort of ICU patients according to a new system that classifies cases according to setting of infection acquisition (community-acquired, early onset hospital-acquired, and late-onset hospital-acquired), anatomical disruption (absent or present with localized or diffuse peritonitis), and severity of disease expression (infection, sepsis, and septic shock). Methods: We performed a multicenter (n = 309), observational, epidemiological study including adult ICU patients diagnosed with intra-abdominal infection. Risk factors for mortality were assessed by logistic regression analysis. Results: The cohort included 2621 patients. Setting of infection acquisition was community-acquired in 31.6%, early onset hospital-acquired in 25%, and late-onset hospital-acquired in 43.4% of patients. Overall prevalence of antimicrobial resistance was 26.3% and difficult-to-treat resistant Gram-negative bacteria 4.3%, with great variation according to geographic region. No difference in prevalence of antimicrobial resistance was observed according to setting of infection acquisition. Overall mortality was 29.1%. Independent risk factors for mortality included late-onset hospital-acquired infection, diffuse peritonitis, sepsis, septic shock, older age, malnutrition, liver failure, congestive heart failure, antimicrobial resistance (either methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci, extended-spectrum beta-lactamase-producing Gram-negative bacteria, or carbapenem-resistant Gram-negative bacteria) and source control failure evidenced by either the need for surgical revision or persistent inflammation. Conclusion: This multinational, heterogeneous cohort of ICU patients with intra-abdominal infection revealed that setting of infection acquisition, anatomical disruption, and severity of disease expression are disease-specific phenotypic characteristics associated with outcome, irrespective of the type of infection. ...
    • File Description:
      STAMPA
    • Relation:
      info:eu-repo/semantics/altIdentifier/pmid/31664501; info:eu-repo/semantics/altIdentifier/wos/WOS:000493268200001; volume:45; issue:12; firstpage:1703; lastpage:1717; numberofpages:15; journal:INTENSIVE CARE MEDICINE; http://hdl.handle.net/11369/397238; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85075166361
    • الرقم المعرف:
      10.1007/s00134-019-05819-3
    • Rights:
      info:eu-repo/semantics/openAccess
    • الرقم المعرف:
      edsbas.DEC87DA8