Contributors: Université Grenoble Alpes (UGA); Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) (IAB); Centre Hospitalier Universitaire CHU Grenoble (CHUGA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA); Hospital del Mar Medical Research Institute Barcelona, Spain (IMIM); Universitat Pompeu Fabra Barcelona (UPF); Centre Hospitalier Universitaire CHU Grenoble (CHUGA); Synchrotron Radiation for Biomedicine = Rayonnement SynchroTROn pour la Recherche BiomédicalE (STROBE); Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes (UGA); Norwegian Institute of Public Health Oslo (NIPH); Centre de Recherche de l’Institut Universitaire en Santé Mentale de Montréal (CRIUSMM); Université de Montréal (UdeM); the Plan Cancer (Canc’Air project), the French Cancer Research Foundation Association de Recherche sur le Cancer – ARC, the French Endowment Fund AGIR for chronic diseases – APMC (projects PRENAPAR and LCI-FOT), the French Endowment Fund for Respiratory Health, the French Fund – Fondation de France (CLIMATHES – 00081169, SEPAGES 5 – 00099903, ELEMENTUM - 00124527).; ANR-19-CE36-0003,EDeN,Exposition précoces aux perturbateurs endocriniens et neurodéveloppement de l'enfant : le rôle de l'axe hypothalamo-hypophysaire(2019); ANR-12-PDOC-0029,PAPER,Grossesse, pollution atmospherique, epigenetique, et sante respiratoire(2012); ANR-14-CE21-0007,SHALCOH,Expositions prénatales aux phénols et santé de l'enfant : analyse longitudinale(2014); ANR-15-IDEX-0002,UGA,IDEX UGA(2015); ANR-15-IDEX-0005,ANR-15- IDEX5,ANR-15- IDEX5; ANR-18-CE36-0005,ETAPE,Exposition prénatale au tabac et à la pollution atmosphérique et effets sur la santé respiratoire et le neurodévelopment de l'enfant: rôle de la méthylation placentaire(2018); ANR-17-CE34-0013,GUMME,Microbiote intestinal dans l'enfance et expositions environnementales maternelles(2017); ANR-21-CE34-0022,MEMORI,Exposition maternelle à un mélange de polluants organiques: marques épigénétiques placentaires et évaluation des risques pour la santé de la descendance(2021); European Project: EST-2019/1/039,ANSES (projet HyPAxE EST-2019/1/039); European Project: 311765,EC:FP7:ERC,ERC-2012-StG_20111109,E-DOHAD(2013); European Project: 308333,EC:FP7:ENV,FP7-ENV-2012-two-stage,HELIX(2013); European Project: 874583,H2020,H2020-EU.3.1.2.,ATHLETE(2020); European Project: 825712,H2020-EU.3.1.1. - Understanding health, wellbeing and disease,H2020-SC1-2018-Single-Stage-RTD,OBERON(2019); European Project: EST-2016-121,ANSES projet CNAP; European Project: EST-2016-121,PENDORE; European Project: EST-2019/1/039,HyPAxE
نبذة مختصرة : International audience ; Abstract We aimed to assess phthalate-hormone associations in the new-generation SEPAGES cohort (2014-2017, France) using improved exposure and outcome assessments. Metabolites from 7 phthalate compounds and the replacement di(isononyl)cyclohexane-1,2-dicarboxylate (DINCH) were measured in within-subject pools of repeated urine samples collected at the second and third pregnancy trimesters (≈21 samples/trimester). Metabolites from 5 steroid hormones were measured in maternal hair samples collected at delivery reflecting on cumulative levels over the previous weeks-months. Adjusted linear regression and bayesian weighted quantile sum (BWQS) mixture models were performed. Each doubling in third trimester urinary MBzP concentrations was associated with average increases of 13.3% (95%CI: 2.65, 24.9) for ∑cortisol, 10.0% (95%CI: 0.26, 20.7) for ∑cortisone, 17.3% (95%CI: 1.67, 35.4) for 11-dehydrocorticosterone and 16.2% (95%CI: 2.20, 32.1) for testosterone, together with a suggestive 10.5% (95%CI: -1.57, 24.1) increase in progesterone levels. Each doubling in second trimester urinary di-isononyl-phthalate (∑DiNP) concentrations was inversely associated with testosterone levels (-11.6%; 95%CI: -21.6, -0.31). For most hormones, a non-significant trend towards a positive phthalate mixture effect was observed at the third but not the second trimester. Our study showed that exposure to some phthalate metabolites, especially MBzP, may affect adrenal and reproductive hormone levels during pregnancy.
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