Additional file 1 of Improved prediction of fracture risk leveraging a genome-wide polygenic risk score

Additional file 1: Fig. S1: Distribution of discrepancies in minor allele frequencies of SNPs between the China Kadoorie Biobank and the UK Biobank; Fig. S2: Distribution of standardized gSOS among 90,172 individuals of European ancestry; Fig. S3: Cumulative incidence of major osteoporotic fracture in (A) the MrOS US cohort and (B) the SOF cohort, and cumulative incidence of hip fracture in (C) the MrOS US cohort and (D) the SOF cohort; Table S1. Summary of model training and selection in the UK Biobank; Table S2. Summary of Pearson correlation between gSOS and clinical risk factors; Table S3. Summary of incidence of osteoporotic fracture; Table S4. Summary of predictive power of gSOS and clinical risk factors; Table S5. Details of net reclassification improvement of major osteoporotic fracture risk prediction using FRAX-gSOS; Table S6. Details of net reclassification improvement of hip fracture risk prediction using FRAX-gSOS.