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SARS-CoV-2 infection prevalence and associated factors among primary healthcare workers in France after the third COVID-19 wave

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  • معلومة اضافية
    • Contributors:
      Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP); Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU); Università di Corsica Pasquale Paoli Université de Corse Pascal Paoli; Partenaires INRAE; Unité des Virus Emergents (UVE); Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM); Fondation Jean Dausset CEPH; Association Française de Pédiatrie Ambulatoire (AFPA); Laboratoire des Multimatériaux et Interfaces (LMI); Université Claude Bernard Lyon 1 (UCBL); Université de Lyon-Université de Lyon-Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS); Hospices Civils de Lyon (HCL); Réseau ReCOL; IQVIA; Santé publique France - French National Public Health Agency Saint-Maurice, France; Virologie (CNRS-UMR3569); Institut Pasteur Paris (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité); Génétique Moléculaire des Virus à ARN - Molecular Genetics of RNA Viruses (GMV-ARN (UMR_3569 / U-Pasteur_2)); Centre National de Référence des virus respiratoires (dont la grippe et le SARS-CoV2) Paris (CNR - laboratoire associé); Institut Pasteur Paris (IP)-Université Paris Cité (UPCité); CHU Saint-Antoine AP-HP; Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU); Assistance Publique - Hôpitaux de Marseille (APHM); This research was funded by Agence Nationale de la Recherche: ANR-20-COV5-0005-01. The CEPH-Biobank is supported by the Ministère de l’Enseignement Supérieur, de la Recherche et de l’Innovation.; ANR-20-COV5-0005,COVID-SeroPRIM,Séroprévalence des IgG dirigées contre le SARS-CoV-2 chez les professionnels de santé en soins primaires et leurs contacts familiaux.(2020)
    • بيانات النشر:
      HAL CCSD
      Nature Publishing Group
    • الموضوع:
      2024
    • نبذة مختصرة :
      International audience ; Abstract Data on the SARS-CoV-2 infection among primary health care workers (PHCWs) are scarce but essential to reflect on policy regarding prevention and control measures. We assessed the prevalence of PHCWs who have been infected by SARS-CoV-2 in comparison with modeling from the general population in metropolitan France, and associated factors. A cross-sectional study was conducted among general practitioners (GPs), pediatricians, dental and pharmacy workers in primary care between May and August 2021. Participants volunteered to provide a dried-blood spot for SARS-CoV-2 antibody assessment and completed a questionnaire. The primary outcome was defined as the detection of infection-induced antibodies (anti-nucleocapsid IgG, and for non-vaccinees: anti-Spike IgG and neutralizing antibodies) or previous self-reported infection (positive RT-qPCR or antigenic test, or positive ELISA test before vaccination). Estimates were adjusted using weights for representativeness and compared with prediction from the general population. Poisson regressions were used to quantify associated factors. The analysis included 1612 PHCWs. Weighted prevalences were: 31.7% (95% CI 27.5–36.0) for GPs, 28.7% (95% CI 24.4–33.0) for pediatricians, 25.2% (95% CI 20.6–31.0) for dentists, and 25.5% (95% CI 18.2–34.0) for pharmacists. Estimates were compatible with model predictions for the general population. PHCWs more likely to be infected were: GPs compared to pharmacist assistants (adjusted prevalence ratio [aPR] = 2.26; CI 95% 1.01–5.07), those living in Île-de-France (aPR = 1.53; CI 95% 1.14–2.05), South-East (aPR = 1.57; CI 95% 1.19–2.08), North-East (aPR = 1.81; CI 95% 1.38–2.37), and those having an unprotected contact with a COVID-19 case within the household (aPR = 1.48; CI 95% 1.22–1.80). Occupational factors were not associated with infection. In conclusion, the risk of SARS-CoV-2 exposure for PHCWs was more likely to have occurred in the community rather than at their workplace.
    • Relation:
      info:eu-repo/semantics/altIdentifier/pmid/38443618; hal-04494616; https://hal.science/hal-04494616; https://hal.science/hal-04494616/document; https://hal.science/hal-04494616/file/s41598-024-55477-9.pdf; PUBMED: 38443618; PUBMEDCENTRAL: PMC10914718
    • الرقم المعرف:
      10.1038/s41598-024-55477-9
    • Rights:
      http://creativecommons.org/licenses/by/ ; info:eu-repo/semantics/OpenAccess
    • الرقم المعرف:
      edsbas.DD04C7A6